在患有性综合征的儿童中,热冲击蛋白70水平
Bağdagül Aksu1, Zeynep Nagehan Yürük Yıldırım2, Asuman Gedikbaşı1
1Department of Pediatric Basic Sciences, Institute of Child Health, İstanbul University, İstanbul, Türkiye.
The Turkish journal of pediatrics
|January 14, 2025
概括
在治疗前,尿液热冲击蛋白70 (uHSP70) 水平在患有类固醇敏感性脏综合征 (SSNS) 的儿童中升高,并且在前尼索隆治疗时降低,这表明脏压力降低. uHSP70可以作为监测治疗反应的生物标志物.
科学领域:
- 儿科脏病学 儿科脏病学
- 生物标志物发现发现
- 淋巴细胞疾病 淋巴细胞疾病
背景情况:
- 异常性性综合征 (NS) 是儿童常见的一种淋巴细胞疾病.
- 热冲击蛋白70 (HSP70) 对细胞应激有反应,包括感染和氧化应激.
- 在类固醇敏感性性综合征 (SSNS) 中研究HSP70可以提供有关疾病机制和治疗反应的见解.
研究的目的:
- 为了评估SSNS.儿童的血清和尿液HSP70水平.
- 评估在普雷迪尼索隆治疗期间HSP70水平的变化.
- 确定HSP70水平是否可以区分频繁和不频繁的复发性SSNS.
主要方法:
- 酶相关免疫吸收试验 (ELISA) 用于测量血清和尿液中的HSP70水平.
- 从36名SSNS患者和35名健康儿童收集了样本,分别在四个时间点进行:治疗前,15,30日和90日.
- 分析了与治疗状态和复发频率相关的HSP70水平.
主要成果:
- 治疗前尿液HSP70 (uHSP70) 和uHSP70/肌素比率在SSNS患者中明显高于对照组 (p<0.0001).
- 在治疗前,SSNS患者的血清HSP70 (sHSP70) 水平较低 (p=0.002).
- 在普得尼索隆治疗期间,uHSP70水平显著下降 (p<0.0001),而在频繁和不频繁的复发者之间没有观察到HSP70水平的显著差异.
结论:
- 在治疗前SSNS患者的uHSP70升高表明脏应激和损伤.
- 降低uHSP70水平与普雷迪尼索隆治疗表明减少脏压力和有效的治疗.
- uHSP70在SSNS中显示出作为监测损伤和治疗反应的生物标志物的潜力,但不区分复发频率.
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