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双响应的微运动药片用于肠道中的向保留in vivo

Zitong An1, Enguang Lin2, Zhiguang Wu3

  • 1Imperial College London South Kensington Campus, London, SW7 2AZ, UK.

Journal of materials chemistry. B
|January 14, 2025
PubMed
概括

这项研究引入了一种新的微发动机平板药丸,用于有效的胃肠道药物输送. 这种磁性驱动的药丸在体内增强了保持力和推进力,克服了当前微/纳米运动平台的局限性.

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Methods for Studying Drug Absorption: In situ01:09

Methods for Studying Drug Absorption: In situ

In situ experiments, such as the Doluisio method and Single-Pass Perfusion technique, provide critical insights into drug uptake by simulating in vivo conditions for drug absorption.
The Doluisio method involves perfusing a prepared segment of a rat's small intestine with a solution of radiolabeled drug and a non-absorbable marker. This helps to differentiate between absorbed and non-absorbed drug concentrations. The intestinal segment is connected at both ends using tubing and syringes,...
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