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Updated: Jun 2, 2025

Efficient Construction of Drug-like Bispirocyclic Scaffolds Via Organocatalytic Cycloadditions of α-Imino γ-Lactones and Alkylidene Pyrazolones
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Efficient Construction of Drug-like Bispirocyclic Scaffolds Via Organocatalytic Cycloadditions of α-Imino γ-Lactones and Alkylidene Pyrazolones

Published on: February 7, 2019

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通过分子内二-氨基酸二烯 (4+3) 循环添加来构建三维复杂性

Lulu Shen1, Tianzhu Qin1, Chongling Jiao1

  • 1State Key Laboratory and Institute of Elemento-Organic Chemistry, College of Chemistry, Frontiers Science Center for New Organic Matter, Nankai University, Tianjin, 300071, P. R. China.

Angewandte Chemie (International ed. in English)
|January 14, 2025
PubMed
概括

研究人员开发了一种新的铜催化 (4+3) 循环添加方法,以高效合成复杂的,富含C(sp3) 的循环胺基架. 这一突破为创造与药物化学和药物发现相关的新分子提供了一个多功能平台.

关键词:
(4+3) 循环加法 (4+3) 循环加法1,3-二极点的电极.2 - - 氨基基酸氨基酸.铜催化剂的使用多环天然产品多环天然产品

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