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Updated: Jun 2, 2025

A Method for Screening and Validation of Resistant Mutations Against Kinase Inhibitors
12:40

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Published on: December 7, 2014

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佩菲西尼布通过向TYK2和JAK/STAT信号传递来抑制扩散型同胞巨细胞瘤

Shan Lu1, Chenxi Cao2,3,4, Wenjia Zhang1

  • 1Institute of Cardiovascular Sciences, School of Basic Medical Sciences, Peking University Health Science Center; Department of Cardiology and Institute of Vascular Medicine, Peking University Third Hospital; State Key Laboratory of Vascular Homeostasis and Remodeling, Peking University, Beijing, 100191, China.

Science China. Life sciences
|January 14, 2025
PubMed
概括

扩散型紧突巨细胞瘤 (dTGCT) 的治疗方法有限. 这项研究揭示了Janus激酶 (JAK) /STAT信号,特别是TYK2,驱动dTGCT,并将peficitinib确定为一种强有力的候选药物.

关键词:
在FLS中,使用FLS.这是JAK/STAT信号.这就是TYK2TYK2.dTGCTCT 的意思是什么?巨细胞是什么?巨细胞是什么?佩菲西尼尼比 (peficitinib) 是一种

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