精神分裂症时间能力受损的相关性:系统性审查
Enrico Croce1, Gabriele Simonelli, Maria Ferrara
1Integrated Department of Mental Health and Pathological Addictions, Health Trust Ferrara, Ferrara, Italy.
The Journal of nervous and mental disease
|January 14, 2025
概括
精神分裂症 (SCZ) 的时间能力受损与症状严重程度和认知缺陷有关. 这些时间问题可能涉及神经回路的改变,这表明精神分裂症治疗的潜在治疗点.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 认知科学 认知科学
背景情况:
- 精神分裂症 (SCZ) 是一种复杂的精神障碍,其特点是显著的认知和功能障碍.
- 对于各种认知功能至关重要的时机能力,在SCZ患者中经常受到干扰.
- 了解这些时间缺陷的相关性对于制定有针对性的干预措施至关重要.
研究的目的:
- 系统地审查和综合现有关于精神分裂症中时间能力受损的临床,认知和神经生物学相关的文献.
- 在SCZ中识别时间表现和症状严重程度,认知功能和神经生物学标志物之间的关联.
主要方法:
- 在PubMed,EMBASE和PsycInfo进行了系统的文献搜索,遵守PRISMA指南.
- 选定的研究检查了SCZ患者的时间能力和症状严重程度,认知测量和神经生物学数据 (成像,EEG) 之间的相关性.
- 总共有45篇文章被纳入了审查中.
主要成果:
- 在SCZ中,受损的时刻表现与积极的,消极的和混乱的症状有关.
- 时间缺陷与执行功能,工作记忆和注意力受损相关.
- 时间障碍与参与运动协调的神经回路的改变有关.
结论:
- 精神分裂症的时机功能障碍与症状严重程度和认知障碍有关.
- 改变的运动协调神经回路可能是这些时间缺陷的基础.
- 需要进一步的研究来阐明病理生理学,并确定SCZ中时间障碍的新疗法标.
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