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在米粒中评估毒性的线性无值概念

Sripati Abhiram Sahoo¹, Jayant Kulkarni², Suvarna Sounderajan³

¹Department of Plant Molecular Biology and Biotechnology, Indira Gandhi Krishi Vishwavidyalaya, Raipur, CG 492012, India; Nuclear Agriculture and Biotechnology Division, Bhabha Atomic Research Centre, Mumbai 400085, India.

Journal of hazardous materials

|January 14, 2025

概括

米中的构成健康风险,即使低于世卫组织限制. 传统的印度方法有效地减少了在米粒中的积累,减轻了潜在的毒性问题.

科学领域:

环境科学环境科学
毒理学毒理学毒理学
食品科学食品科学食品科学

背景情况:

(As) 是一种主要的致癌物质,通过全球主食大米进入人类饮食.
大米种植区经常被污染,造成严重的公共卫生问题.

研究的目的:

评估来自孟买/纳维-孟买的米粒中的含量.
为了评估与食用来自大米的素摄入相关的健康风险.
调查传统印度方法在减少大米中积累的有效性.

主要方法:

来自41个地点的500个大米粒样本的市场调查.
根据积累 (低,中,高) 的水样本的分类.
使用危险系数和饮食摄入量估计的健康风险评估.
通过煮和基于吸收的制来分析的减少.
在体外研究取物对小鼠淋巴细胞 (ROS和GSH水平) 的影响.

主要成果:

很大一部分大米样本,即使低于世卫组织允许的限值,也表明健康风险 (危险系数>1).
传统的印度方法 (再煮和吸收) 减少了大约0.4倍的积累.
科拉姆大米提取物在小鼠淋巴细胞中诱导氧化应激 (增加ROS,减少GSH),表明有氧还原失衡.

结论:

大米中污染对健康构成风险,需要仔细评估.
传统的方法有效地减轻了来自大米的暴露.
推使用线性无值模型来评估人类食用的污染大米的安全性.

关键词:

的毒性的毒性葡萄糖氨酸 (Glutathione) 是一种危险系数 (Hazard quotient) 是指一个危险系数.线性-没有值.沸式的沸方式有反应性氧气物种.

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Atomic Absorption Spectroscopy: Lab

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For AAS measurements, samples must be introduced as clear solutions, often requiring extensive preliminary treatment to dissolve materials like soils, animal tissues, and minerals. Common methods for sample preparation include treatment with hot mineral acids, wet ashing, combustion in closed containers, high-temperature ashing, or fusion with reagents.
Solutions containing organic solvents, such as low-molecular-mass alcohols, esters, or ketones, enhance absorbances by increasing...