通过ain-cyclodextrin纳米颗粒提升环林的生物可访问性:模拟胃肠道消化和细胞吸收研究
Peifang Chen1, Yong Wang2, Zizhe Cai1
1Department of Food Science and Engineering, Jinan University, Guangzhou 510632, China.
Food chemistry
|January 14, 2025
概括
扎因-环氧素纳米颗粒有效地通过口服提供环氧. 这些纳米粒子提高了稳定性,生物可用性和细胞吸收,为口服输送系统提供了一个有前途的战略.
科学领域:
- 食品科学与技术 食品科学与技术
- 生物材料科学 生物材料科学
- 药理学 药理学是指药理学的学科.
背景情况:
- 环类 (CLSs) 是在亚麻种中发现的生物活性疏水性循环.
- 开发有效的CLS口服输送系统是具有挑战性的,因为他们的属性.
研究的目的:
- 开发Zin (Z) - 环极素 (CD) 二元纳米粒子 (NP) 来增强CLSs的口服输送.
- 研究CLS载荷NP的物理化学特性,稳定性和生物可访问性.
主要方法:
- 制造装有CLSs的简-环极二元纳米粒子.
- 纳米粒子尺寸的表征,封装效率,在各种条件下 (热,pH,储存) 的稳定性.
- 在实验室中评估CLS释放,生物可访问性和细胞吸收机制 (脂质介导的内细胞分裂).
主要成果:
- 与单独使用Zin NPs相比,Z-CD NPs的颗粒大小更小,CLS封装性能更好.
- 结合CD增强了NP的热,pH和储存稳定性.
- 载有CLS的Z-CDNP显著改善了生物可访问性 (高达86.71%),并促进了细胞吸收.
- CD 阻止了胃中早期的CLS释放,并在消化后增强了吸收.
结论:
- Zein-cyclodextrin二元纳米颗粒代表了一个可行的和有效的系统,用于口服输送环林.
- 添加环极素显著提高了CLS载荷纳米粒子的稳定性,生物可访问性和细胞吸收.
- 这种方法提供了一种有前途的策略,可以提高像CLSs这样的疏水生物活性化合物的口服输送效率.
相关概念视频
Factors Affecting Dissolution: Drug Permeability, Stability and Stereochemistry
173
Orally administered drugs primarily enter the systemic circulation via passive diffusion through the intestinal membranes. The drug's absorption is influenced by drug stability in the gastrointestinal GI tract, membrane permeability, the surface area available for absorption, luminal drug concentration, and residence time in the lumen. Drug permeability can be enhanced by adjusting the lipophilicity, polarity, or molecular size of the drug, promoting its passive transport across intestinal...
173
Methods for Studying Drug Absorption: In vitro
199
In vitro experiments are crucial for understanding the transport and absorption of drugs through biological materials. These studies employ varied methods such as the diffusion cell method, the everted sac technique, and the everted ring technique.
The diffusion cell method uses a two-compartment cell, including a donor compartment with the drug solution, which simulates the environment where the drug is applied, and a receptor compartment with a buffer solution, which simulates the environment...
The diffusion cell method uses a two-compartment cell, including a donor compartment with the drug solution, which simulates the environment where the drug is applied, and a receptor compartment with a buffer solution, which simulates the environment...
199
Factors Influencing Drug Absorption: Physicochemical Parameters
210
The physicochemical characteristics of drugs play a crucial role in formulating stable and bioavailable drug products. The solubility of a drug, governed by the varying pH along the GI tract and its dissociation constant (pKa), is pivotal in determining its ionization state and absorption rate. Notably, weak acids and bases remain unionized and are absorbed more rapidly.
Enhanced drug absorption can be achieved by reducing particle sizes and increasing surface areas, thereby facilitating...
Enhanced drug absorption can be achieved by reducing particle sizes and increasing surface areas, thereby facilitating...
210
Factors Influencing Bioavailability: First-Pass Elimination
6.1K
When a drug is taken orally, it undergoes a journey starting from the gastrointestinal (GI) tract, passing through the portal vein, reaching the liver, and finally entering the systemic circulation. This process involves the absorption of the drug across the GI tract. The liver is the primary site for metabolizing the drug, with some metabolism also occurring in the gut wall. This journey significantly reduces the quantity of the drug that reaches the systemic circulation, a phenomenon known as...
6.1K
Methods for Studying Drug Absorption: In situ
201
In situ experiments, such as the Doluisio method and Single-Pass Perfusion technique, provide critical insights into drug uptake by simulating in vivo conditions for drug absorption.
The Doluisio method involves perfusing a prepared segment of a rat's small intestine with a solution of radiolabeled drug and a non-absorbable marker. This helps to differentiate between absorbed and non-absorbed drug concentrations. The intestinal segment is connected at both ends using tubing and syringes,...
The Doluisio method involves perfusing a prepared segment of a rat's small intestine with a solution of radiolabeled drug and a non-absorbable marker. This helps to differentiate between absorbed and non-absorbed drug concentrations. The intestinal segment is connected at both ends using tubing and syringes,...
201
Factors Influencing Drug Absorption: Drug Dissolution
404
The pharmacokinetic journey of drugs from solid oral dosage forms into systemic circulation is multifaceted. It begins with disintegration, a prerequisite ensuring a solid dosage form's subdivision into minute particles. Dissolution occurs next as these granulated entities solubilize in gastrointestinal fluids. This solubilization is crucial for the succeeding stage, permeation, which describes the traversal of the drug across the intestinal membrane and its subsequent entry into the blood...
404


