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Heart Failure Drugs: Inotropic Agents

Heart Failure Drugs: Inotropic Agents

Positive inotropic agents are commonly used as the first line of treatment for heart failure. One such agent is digoxin, derived from the genus Digitalis, which has been known for centuries but effectively utilized since 1785. However, these cardiac glycosides can have potentially toxic effects due to their mechanism of action, which involves inhibiting Na+/K+-ATPase and increasing contractility. Digoxin is absorbed orally and distributed in various tissues, including the CNS. It has a long...

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An Injectable and Drug-loaded Supramolecular Hydrogel for Local Catheter Injection into the Pig Heart

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可注射的离子凝导体:先进的材料设计可以改变心脏节奏.

Gabriel J Rodriguez-Rivera¹, Allison Post², Mathews John²

¹McKetta Department of Chemical Engineering, The University of Texas at Austin, Austin, TX, 787212, USA.

|January 14, 2025

概括

研究人员开发了一种可注射的水凝电极来加快心脏组织的节奏,从而有可能预防心室节律失常并避免痛苦的除. 这种新型电极通过冠状动脉导航,为心脏病提供了不那么侵入性的治疗方法.

关键词:

节律失常是一种失常.生物材料是一种生物材料.导电性导电性导电性水凝是一种水凝.可以注射的注射剂节奏节奏是指节奏的节奏.

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Fabrication of Myogenic Engineered Tissue Constructs

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科学领域:

生物材料科学生物材料科学
心血管工程心血管工程
医疗器械医疗器械

背景情况:

心室心律不整通常是由心肌中部的重新进入电路引起的.
由于电极尺寸的限制,当前的节拍方法难以到达这些深心肌区域.
现有的治疗方法,如除和移除,可能是痛苦和侵入性的.

研究的目的:

开发一种可注射,导电的水凝电极,用于节奏中心肌组织.
为了克服电流电极在进入冠状动脉中的局限性.
为了创造一种不那么侵入性的除和心脏移除的替代方案.

主要方法:

开发了一种新型的聚乙尿二烯胺宏聚合物凝,与心肌硬度相匹配.
向水凝传递离子导电性,达到2-3X的本源心肌水平.
使用双筒注射器与混合头用于快速的现场氧化还原启动固化.
在ex vivo猪模型中评估水凝粘度和治愈率.
在猪模型中证明了体内部署和节奏效果.

主要成果:

水凝电极的导电性与原生心肌相提并论,在植入后仍保留.
稳定的电刺激在多个周期和相当长的心脏静脉中实现.
可注射的水凝在体内成功填充了冠状动脉,达到比当前技术更深,更精细的区域.
水凝表现出适合于均部署的粘度和固化率.

结论:

可注射的离子凝电极显示出前所未有的中心肌组织节奏节奏的希望.
这项技术为无痛除和改善心室节律失常的治疗提供了潜在的途径.
开发的水凝材料稳定,导电性强,适合微创心脏干预.