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短期表面温度暴露与人类凝血之间的关联:来自北京的时间序列研究,2014-2023年
Yi Zhang1, Tiancheng Wang2, Jiaqi Shi1
1Department of Occupational and Environmental Health Sciences, School of Public Health, Peking University, Beijing 100191, China; Beijing Key Laboratory of Toxicological Research and Risk Assessment for Food Safety, School of Public Health, Peking University, Beijing 100083, China.
极端的高温和低温都会增加血液凝结能力,增加血栓栓塞性疾病的风险. 这项研究将表面温度与关键的凝血变化联系起来,证实了不同人群中的风险.
科学领域:
- 环境健康 环境健康
- 心血管科学 心血管科学
- 血液学 血液学 血液学
背景情况:
- 不理想的环境温度与血栓栓塞性疾病发病率和死亡率的增加有关.
- 表面温度 (AT) 影响血液凝固,这是血栓形成的关键因素.
研究的目的:
- 为了研究表面温度 (AT) 与血液凝结指数之间的关联.
- 为了确定热和冷对高凝血状态和血栓栓塞风险的影响.
主要方法:
- 对18894名参与者的时间序列分析 (北京,2014-2023) 和对20549名参与者的验证.
- 使用温度,湿度和风速数据计算每日平均AT.
- 一般化添加模型和后勤回归来分析AT-凝血关联.
主要成果:
- 热能缩短了前热血时间和激活了部分血栓塑时间;冷能缩短了血时间.
- 纤维素素在高温和低温时都增加.
- 在高温和低温下,高凝血状态的风险增加,在极热下显著增加.
结论:
- 冷和热都通过不同的凝血级联路径增加了血液凝结能力.
- 表面温度显著影响凝血,增加了血栓塞栓性疾病的风险.
- 调查结果在子组和验证分析中是稳定的,突出显示环境温度是危险因素.
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