粮农组织/世卫组织/联合国统一组织的基础代谢率作为胃癌患者存活的预后因素:一个队列研究
Soomin An1, Wankyu Eo2, Seol Bin Kim1
1Department of Nursing, Dongyang University, Gyeongbuk, Republic of Korea.
Medicine
|January 14, 2025
概括
基础代谢率 (BMR) 预测了手术后胃癌患者的生存率. 较高的FWU BMR值与降低的死亡风险相关,改善了个性化护理的预后准确性.
科学领域:
- 在瘤学瘤学.
- 代谢过程中的代谢.
- 生物统计学 生物统计学
背景情况:
- 基本代谢率 (BMR) 反映了休息的能量消耗和代谢需求.
- 胃癌的预后对于手术后的管理至关重要.
- 准确的预后标志物对于个性化患者护理至关重要.
研究的目的:
- 为了评估胃癌患者经历治疗切除的BMR的预后意义.
- 评估一个包含FWU BMR的模型对整体存活 (OS) 的预测性能.
主要方法:
- 对521名I-III期胃癌患者的回顾性分析.
- 使用粮食和农业组织/世界卫生组织/联合国大学 (FWU) 方程计算的BMR.
- 多变量考克斯回归和分数多项式建模用于分析BMR对OS的影响.
主要成果:
- FWU BMR 是 OS 的一个显著预测因素 (P < .001).
- 在FWU BMR和OS之间存在线性关系;更高的BMR与较低的死亡率相关.
- 与没有BMR的模型相比,结合FWU BMR的FWU模型显示出更好的预测性能 (C指数:0.815,IAUC:0.775).
结论:
- 胃癌患者切除后的FWU BMR是一个有价值的预后因素.
- 结合FWU BMR可以提高整体生存时间的预测准确性.
- 这些发现支持在胃癌的个性化术后护理策略中使用FWU BMR.
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