轮班工作和CLOCK,BMAL1和PER1基因多态与卫生保健工作者高血压的相关性:一个横截面研究
Qiang Min1,2, Wanglin Hu1, Dan Lei1
1Department of Neurosurgery, Wuhan Hanyang Hospital, Wuhan, Hubei, China.
Medicine
|January 14, 2025
概括
某些昼夜钟基因多态,特别是CLOCK和BMAL1,可能会保护医疗保健工作者免受高血压. 轮班工作,睡眠不足和家族病史仍然是显著的高血压风险因素.
科学领域:
- 时间生物学和心血管健康
- 高血压的分子流行病学
- 在医疗保健机构的职业健康.
背景情况:
- 循环时钟基因 (CLOCK,BMAL1,PER1) 调节生理过程,它们的干扰与各种疾病有关.
- 轮班工作是心血管问题的已知危险因素,包括高血压,可能是由于昼夜节律的扰乱.
- 了解基因与环境的相互作用,如轮班工作和遗传多态性,对于确定高血压易感性至关重要.
研究的目的:
- 调查昼夜钟基因 (CLOCK,BMAL1,PER1) 中的多态化与医疗保健工作者高血压风险之间的关联.
- 检查轮班工作模式和特定基因多态化对高血压发展的综合影响.
- 在医疗保健专业人员中确定高血压的关键风险因素.
主要方法:
- 招募了222名医疗保健工作者 (76名高血压患者,146名对照患者),并收集了人口统计和工作时间表数据.
- 在CLOCK,BMAL1和PER1基因中的基因型单核酸多态 (SNPs) 使用聚合酶连锁反应-限制片段长度多态.
- 采用多变量逻辑回归来分析生活方式因素,基因多态,轮班工作和高血压之间的关联.
主要成果:
- 在CLOCK rs1801260的GG基因型和在BMAL1 rs11022775的TT基因型与降低高血压风险有关.
- 轮班工作,特别是每月更高数量的夜班,与高血压风险有积极的相关性.
- 家庭高血压史和睡眠时间不足是高血压的重要独立风险因素.
结论:
- 在CLOCK和BMAL1基因中的特定多态可能会在这个医疗保健工作者队列中产生对高血压的保护作用.
- PER1基因多态性与高血压风险没有显著关联.
- 轮班工作模式 (尤其是夜班),睡眠不足和积极的家族病史是卫生保健工作者高血压的关键风险因素.
相关概念视频
Circadian Rhythms and Gene Regulation
4.0K
The biological clock is involved in many aspects of regulating complex physiology in all animals. It was in 1935 when German zoologists, Hans Kalmus and Erwin Bünning, discovered the existence of circadian rhythm in Drosophila melanogaster. However, the internal molecular mechanisms behind the circadian clock remained a mystery until 1984, when Jeffrey C. Hall, Michael Rosbash, and Michael W. Young discovered the expression of the Per gene oscillating over a 24-hour cycle. In subsequent...
4.0K
Factors affecting Blood pressure
3.0K
Several physiological and lifestyle factors influence blood pressure (BP). Understanding these factors is crucial as they are significant in patient education and blood pressure management.
Physiological Factors:
Physiological Factors:
3.0K
Errors occurring during blood pressure monitoring
590
Blood pressure monitoring is a crucial clinical procedure in diagnosing and managing various cardiovascular conditions. Despite its significance, the accuracy of blood pressure measurements can be compromised by multiple factors, potentially leading to either falsely high or low readings. These inaccuracies are critical as they can significantly impact patient care. So, it is vital to understand these challenges deeply and adopt strategic approaches to minimize errors.
Several factors...
Several factors...
590
Alterations in Blood Pressure
1.2K
Alterations in blood pressure, such as hypertension (high blood pressure) and hypotension (low blood pressure), significantly affect human health. Understanding these conditions' classifications, causes, and symptoms is essential for effective management and treatment.
Hypertension (High blood pressure)
Hypertension occurs when blood pressure readings consistently exceed the normal range. It is diagnosed when systolic blood pressure (the top number, indicating pressure while the heart...
Hypertension (High blood pressure)
Hypertension occurs when blood pressure readings consistently exceed the normal range. It is diagnosed when systolic blood pressure (the top number, indicating pressure while the heart...
1.2K
Hypertension and Regulation of Blood Pressure
1.9K
Hypertension, the most common cardiovascular disease, is diagnosed through repeated measurements of elevated blood pressure. Its risks, including damage to the kidney, heart, and brain, are directly proportional to blood pressure levels. Starting from 115/75 mm Hg, the risk of cardiovascular disease doubles with each increment of 20/10 mm Hg. The diagnosis relies on blood pressure measurements, not on patient symptoms, as hypertension is often asymptomatic until end-organ damage is imminent or...
1.9K
Human Genetics
529
Human genetics provides a profound framework for understanding the interplay between genetic predispositions and human psychology. At the heart of this discipline lies the study of how genes influence physical traits, behaviors, and susceptibility to diseases. Each person carries a unique genetic code that subtly or significantly shapes their psychological and behavioral landscape.
The complex relationship between genetics and psychology is observable through common biological components such...
The complex relationship between genetics and psychology is observable through common biological components such...
529


