胚胎瘤具有多层红,DICER1突变,在化疗放射治疗后显示出组织学上独特的神经元分化
Ayako Yamazaki1, Chikako Kiyotani2, Kimikazu Matsumoto2
1Department of Human Pathology, Gunma University Graduate School of Medicine, Maebashi, Japan.
概括
带有多层红的胚胎瘤 (ETMRs) 是婴儿罕见的侵袭性脑瘤. 这一案例揭示了DICER1突变ETMR的独特后处理变化,包括成熟和典型特征的丧失.
科学领域:
- 儿科神经瘤学 儿童神经瘤学
- 分子神经病理学分子神经病理学
- 癌症生物学 癌症生物学
背景情况:
- 带有多层红的胚胎瘤 (ETMRs) 是具有攻击性的儿科脑瘤.
- ETMR的特征是C19MC变异或DICER1突变.
- 治疗后C19MC改变ETMR的组织学变化已被记录,但在DICER1突变ETMR中没有.
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