PWWP2A/B: 蛋白质组景观中的突出参与者
Saravanaraman Ponne1, Raj Kumar Chinnadurai2, Rajender Kumar3
1Department of Medical Biotechnology, Aarupadai Veedu Medical College and Hospital, Vinayaka Mission's Research Foundation (Deemed to be University), Puducherry 607403, India.
Gene
|January 14, 2025
概括
PWWP2A和PWWP2B蛋白对细胞过程至关重要,并且与胃癌有关. 准PWWP2-miRNA-TGF-β通路为疾病提供了潜在的治疗策略.
科学领域:
- 表观遗传学和分子生物学
- 癌症研究 癌症研究
- 细胞生物学 细胞生物学
背景情况:
- PWWP域是一个真核动机,对染色体协会和细胞功能至关重要.
- PWWP2A和PWWP2B是与DNA甲基转移酶相关的蛋白质,涉及发育,线粒分裂和DNA修复.
- PWWP2B的失调与胃癌的进展有关.
研究的目的:
- 探索PWWP2A和PWWP2B在细胞过程和疾病中的作用.
- 研究PWWP2-miRNA-TGF-β信号轴及其治疗潜力.
主要方法:
- 文献审查和对PWWP2A和PWWP2B现有研究的分析.
- 检查PWWP2-miRNA相互作用及其对TGF-β信号传递的影响.
- 在瘤侵入性的背景下分析PWWP2-P4HA3相互作用.
主要成果:
- PWWP2A和PWWP2B参与胚胎发育,线粒调节和DNA损伤反应.
- PWWP2B下调促进胃癌细胞的增殖和迁移.
- 圆形RNAcPWWP2A通过隔离特定的微RNA来调节TGF-β信号传递.
结论:
- PWWP2A和PWWP2B蛋白质是基本细胞过程中的关键调节者.
- 包括PWWP2-P4HA3相互作用在内的PWWP2-miRNA-TGF-β轴呈现出有前途的治疗标.
- PWWP2A和PWWP2B是治疗干预在表观遗传和疾病背景的重要目标.
关键词:
癌症 癌症 癌症 癌症表观遗传学 在表观遗传学中,表观遗传学是指表观遗传学.纤维化 纤维化 纤维化在 H2A.Z 相互作用原子中.在P4HA3中.这是一种PWWP蛋白质.在TGF-β的基础上.这是一个小RNARNA.更多相关视频
07:38Mass Spectrometry-Based Proteomics Analyses Using the OpenProt Database to Unveil Novel Proteins Translated from Non-Canonical Open Reading Frames
Published on: April 11, 2019
12.7K
16:36Proteomics to Identify Proteins Interacting with P2X2 Ligand-Gated Cation Channels
Published on: May 18, 2009
14.6K
相关概念视频
01:33Proteomics
7.2K
A proteome is the entire set of proteins that a cell type produces. We can study proteomes using the knowledge of genomes because genes code for mRNAs, and the mRNAs encode proteins. Although mRNA analysis is a step in the right direction, not all mRNAs are translated into proteins.
Proteomics is the study of proteomes' function. It involves the large-scale systematic study of the proteome to denote the protein complement expressed by a genome. Scientist Mark Wilkins coined the term...
Proteomics is the study of proteomes' function. It involves the large-scale systematic study of the proteome to denote the protein complement expressed by a genome. Scientist Mark Wilkins coined the term...
7.2K
02:24Ribosome Profiling
3.5K
Ribosome profiling or ribo-sequencing is a deep sequencing technique that produces a snapshot of active translation in a cell. It selectively sequences the mRNAs protected by ribosomes to get an insight into a cell’s translation landscape at any given point in time.
Applications of ribosome profiling
Ribosome profiling has many applications, including in vivo monitoring of translation inside a particular organ or tissue type and quantifying new protein synthesis levels.
The technique...
Applications of ribosome profiling
Ribosome profiling has many applications, including in vivo monitoring of translation inside a particular organ or tissue type and quantifying new protein synthesis levels.
The technique...
3.5K
02:04Covalently Linked Protein Regulators
6.8K
Proteins can undergo many types of post-translational modifications, often in response to changes in their environment. These modifications play an important role in the function and stability of these proteins. Covalently linked molecules include functional groups, such as methyl, acetyl, and phosphate groups, and also small proteins, such as ubiquitin. There are around 200 different types of covalent regulators that have been identified.
These groups modify specific amino acids in a protein....
These groups modify specific amino acids in a protein....
6.8K