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拉丁美洲SLE怀孕中的孕产妇和胎儿结局:系统审查和元分析

Jairo Cajamarca-Baron¹, Catalina Sanmiguel-Reyes², Juan Esteban Bedoya-Loaiza²

¹Rheumatologist, Hospital San José. Research Professor - Research Institute, Fundación Universitaria de Ciencias de la Salud (FUCS), Bogotá 111411, Colombia.

Autoimmunity reviews

|January 14, 2025

概括

患有全身性狼发疹 (SLE) 的拉丁裔孕妇面临更高的孕前和早产风险. 狼性炎显著增加了孕前的风险,强调了需要专业护理的需要.

科学领域:

产科和妇科产科和妇科
类风湿病学类风湿病学
孕产妇和胎儿医学孕产妇和胎儿医学

背景情况:

系统性红斑狼 (SLE) 不成比例地影响生育年龄的女性,增加怀孕风险.
拉丁裔女性患有SLE的诊断年龄较小,增加了对妊娠并发症的易感性,如先兆子和胎儿生长限制.

研究的目的:

系统地审查患有SLE的孕妇拉丁裔妇女的孕妇和胎儿结局.
进行一项元分析,评估该人群中疾病特异性风险.

主要方法:

系统性审查遵循PRISMA指南,搜索PubMed和SciELO对SLE和拉丁美洲怀孕的研究,直到2022年12月.
包括病例报告,队列研究和涉及SLE孕妇的临床试验.
分析的重点是先兆子和狼性炎,计算相对风险 (RR).

主要成果:

分析了44项涉及2190例怀孕的研究.
报告的高发育前 (11-52%),早产 (18.6-70.8%) 和胎儿损失率.
在拉丁美洲,胎儿死亡率在过去的几十年中一直在下降 (1980-1999年为35%,2020-2023年为10%).
狼性炎几乎使孕前的风险增加了一倍 (RR = 1.89,95% CI: 1.40-2.55).

结论:

患有SLE的拉丁裔女性经历了不良妊娠结果的风险增加,包括先兆子和早产.
狼性炎和活跃性疾病是关键的危险因素.
定制的护理和早期干预对于改善孕产妇和胎儿健康结果至关重要.

关键词:

拉丁美洲拉丁美洲拉丁美洲怀孕的结果怀孕的结果系统性红血性狼 (Systemic lupus erythematosusus) 是一种全身性狼.

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