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Updated: Jun 2, 2025

In Vitro Establishment of a Genetically Engineered Murine Head and Neck Cancer Cell Line using an Adeno-Associated Virus-Cas9 System
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Published on: January 9, 2020

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实验室NIH3T3小鼠胚胎纤维细胞模型没有预测AAV2或AAVdj介导的细胞转化

Luping Qiu1, Steven W Kumpf1, Elias M Oziolor1

  • 1Drug Safety Research & Development, Pfizer, Inc., Groton, CT 06340, USA.

Toxicology and applied pharmacology
|January 14, 2025
PubMed
概括

再组合腺相关病毒 (rAAV) 基因疗法在体外没有显示细胞转化,这表明细胞转化试验可能无法预测小鼠肝细胞癌风险.

关键词:
克里斯普尔-Cas9是什么意思细胞转化细胞的转化低附着度测试的增长美国国家卫生研究院 (NIH3T3T3)软菌殖民地形成试验试验rAAAVAV 在这里.

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In-vitro Mutagenesis01:16

In-vitro Mutagenesis

To learn more about the function of a gene, researchers can observe what happens when the gene is inactivated or “knocked out,” by creating genetically engineered knockout animals. Knockout mice have been particularly useful as models for human diseases such as cancer, Parkinson’s disease, and diabetes.
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