1型糖尿病和妊娠中的血栓塞栓症
Jacob Thomas1, Charles Brewerton1, Calla Holmgren2
1Ascension St. Alexius Department of Obstetrics and Gynecology, Hoffman Estates, Illinois.
American journal of perinatology
|January 14, 2025
概括
1型糖尿病 (T1DM) 在怀孕和产后期间显著增加危险血栓的风险. 这项研究发现T1DM独立地与较高的肺栓塞率和深静脉血栓形成有关.
科学领域:
- 产科和妇科 产科和妇科
- 内分泌学 在内分泌学.
- 心血管医学 心血管医学
背景情况:
- 怀孕期间1型糖尿病 (T1DM) 的管理是复杂的.
- T1DM与与怀孕相关的血栓栓塞瘤之间的关联仍然不清楚.
- 这项研究调查了T1DM对孕妇和产后患者血栓事件的影响.
研究的目的:
- 为了确定T1DM是否会增加怀孕期间和产后发生血栓栓塞事件的风险.
- 为了比较T1DM和没有T1DM的孕妇中血栓事件的发生率.
- 确定与T1DM相关的特定类型的血栓栓塞事件.
主要方法:
- 使用国家住院患者样本数据库 (2017-2019) 进行回顾性队列研究.
- 与没有T1DM的孕妇和产后患者的比较.
- 主要结局:任何血栓性疾病 (PE,DVT,CVT) 的综合诊断.
- 逻辑回归分析对混因子进行了控制.
主要成果:
- T1DM患者 (0.4%的队列) 患有较高的血栓栓塞率 (0.45%与0.20%,p < 0.001).
- T1DM独立地与任何血栓栓塞事件 (aOR=2.19),PE (aOR=3.59) 和DVT (aOR=2.43) 的概率增加有关.
- 深静脉血栓塞 (DVT) 是最常见的事件.
结论:
- 1型糖尿病是与怀孕相关的血栓栓塞事件的独立风险因素.
- 肺栓塞和深静脉血栓是最常见的表现.
- 第1型糖尿病对静脉瘤风险的影响与肥胖的影响相当.
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