在血造造干细胞移植后的患者中优先考虑妇科护理
Arpita Jain1, Monna Pandurangi2, Dhaarani Jayaraman3
1Reproductive Medicine and Surgery, Sri Ramachandra Medical College and Research Institute, Chennai, Tamil Nadu, India.
BMJ case reports
|January 14, 2025
概括
本案例研究显示,在干细胞移植后,慢性移植对宿主疾病 (cGvHD) 的罕见妇科并发症. 早期妇科监测对于检测和管理生殖器cGvHD至关重要,以预防严重问题.
科学领域:
- 在瘤学瘤学.
- 血液学 血液学 血液学
- 妇科 妇科医生 妇科
背景情况:
- 急性髓性白血病 (AML) 的治疗包括化疗和血造干细胞移植 (HSCT).
- 慢性移植对宿主疾病 (cGvHD) 是一种潜在的HSCT后并发症,影响各种器官.
- cGvHD的妇科表现不常见,但可能导致显著的发病率.
研究的目的:
- 报告一个沉默的生殖器cGvHD病例,表现为二次 amenorrhoea 和阴道粘附.
- 突出后HSCT患者妇科监测的重要性.
- 强调妇科cGvHD的积极管理,以防止不可逆转的并发症.
主要方法:
- 一个青少年女性的病例报告,用HSCT治疗AML.
- 诊断原发性卵巢衰竭,并随后对二次 amenorrhoea进行检查.
- 临床检查,激素评估,超声波和生殖器cGvHD的手术干预.
主要成果:
- 由于化疗引起的原发性卵巢衰竭,患者患上了二次异常流产.
- 诊断出沉默的生殖器cGvHD,导致阴道粘附,血栓塞和血液计.
- 手术管理,局部雌激素,阴道模具和HRT导致恢复月经和症状消失.
结论:
- 生殖器cGvHD可以潜伏地呈现并导致严重的妇科并发症.
- 常规妇科监测对于HSCT接受者的长期随访至关重要.
- 及时诊断和多学科管理可以防止不可逆转的损害,改善生活质量.
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