在年轻成年人中,抑郁症的多基因风险和子前带状皮层的静止状态功能连接性
Yu Chen1, Huey-Ting Li2, Xingguang Luo2
1From the Department of Psychiatry, Yale University School of Medicine, New Haven, Conn., USA (Chen, Luo, Ide, C.-S. Li); Yale University, New Haven, Conn., USA (H.-T. Li); the Department of Biomedical Engineering, College of Chemistry and Life Science, Beijing University of Technology, Beijing, China (G. Li); the Beijing International Science and Technology Cooperation Base for Intelligent Physiological Measurement and Clinical Transformation, Beijing, China (G. Li); the Department of Neuroscience, Yale University School of Medicine, New Haven, Conn., USA (C.-S Li); the Interdepartment Neuroscience Program, Yale University, New Haven, Conn., USA (C.-S. Li); the Wu Tsai Institute, Yale University, New Haven, Conn., USA (C.-S. Li) yu.chen.yc838@yale.edu.
遗传变异通过改变大脑连接来影响抑郁风险. 前环状皮层 (sgACC) 下静止状态功能连接 (rsFC) 与年轻成年人患抑郁症和症状严重程度的多基因风险有关.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 遗传学 是一个遗传学.
背景情况:
- 遗传变异通过影响大脑结构和功能,有助于抑郁风险.
- 在抑郁症中,前环状皮层 (sgACC) 起着至关重要的作用.
- 研究sgACC静止状态功能连接 (rsFC) 与亚临床人群中抑郁症多基因风险之间的联系是重要的.
研究的目的:
- 研究sgACC rsFC与抑郁症多基因风险评分 (PRS) 之间的关联.
- 在健康的年轻成年人中探索 sgACC rsFC 和抑郁症症状严重程度之间的关系.
- 为了确定这些协会中的潜在的性别差异.
主要方法:
- 基于种子的全脑sgACC rsFC是使用人类结合体项目的数据进行计算的.
- 对717名健康的年轻成年人计算了抑郁症的多基因风险评分 (PRS).
- 进行全脑回归分析,控制共变量,并在经过校正的值时评估结果.
主要成果:
- 较低的sgACC rsFC与默认模式网络和前部区域与更高的PRS相关.
- 较低的sgACC-大脑小脑rsFC与更大的抑郁症症状严重程度有关.
- 在PRS和抑郁症严重程度的连接相关性中观察到性别差异;PRS也与体质投诉相关.
结论:
- 基于sgACC的独特网络与年轻成年人的遗传倾向和亚临床抑郁症的表现有关.
- 将抑郁风险与严重性标志物区分开来,可以为早期和有效的干预提供信息.
- 这些发现是针对亚临床抑郁症的,可能不适用于已诊断的抑郁症.
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