中国内脏肥胖指数轨迹和前糖尿病和糖尿病中风:一个前性队列研究
Qitong Liu1, Ming Sun1, Yang Liu1
1Key Laboratory of Environmental Stress and Chronic Disease Control & Prevention, Department of Biostatistics and Epidemiology, Ministry of Education, School of Public Health, China Medical University, Shenyang, China.
Diabetes/metabolism research and reviews
|January 14, 2025
概括
持久高的中国内脏脂肪指数 (CVAI) 在糖尿病和糖尿病前期患者中显著增加中风风险,特别是缺血性中风. 保持低CVAI对于预防中风至关重要.
科学领域:
- 内分泌学 在内分泌学.
- 心血管医学 心血管医学
- 流行病学 流行病学
背景情况:
- 脑卒中是糖尿病患者常见的并发症.
- 中国内脏脂肪指数 (CVAI) 与传统标志物相比,是内脏脂肪的优秀指标.
- 在糖尿病前期和糖尿病人群中,CVAI变化与中风风险之间的关联需要进一步研究.
研究的目的:
- 研究中国内脏脂肪指数 (CVAI) 的不同轨迹与糖尿病和糖尿病前期患者中风风险之间的关系.
- 为了确定与中风发病率增加相关的特定CVAI模式.
主要方法:
- 一项前性队列研究涉及11,339名糖尿病前期和糖尿病参与者,来自Kailuan研究.
- 基于重复测量,使用隐性混合模型来定义四个不同的CVAI轨迹.
- 考克斯的比例危险回归模型被用来评估CVAI轨迹与中风风险之间的关联.
主要成果:
- 确定了四个CVAI轨迹组:低稳定,中等低稳定,中等高稳定和高增长.
- 与低稳定组相比,中度高稳定 (HR:1.50) 和高增加 (HR:2.15) CVAI轨迹与整体中风风险更高有显著的相关性.
- 中度高稳定 (HR: 1.70) 和高增加 (HR: 2.53) 的CVAI组显示出缺血性中风的风险明显增加,但没有出血性中风.
结论:
- 长期升高的CVAI水平与患有糖尿病和糖尿病的患者中风风险增加有关,特别是缺血性中风.
- 保持较低的CVAI水平与中风风险降低有关.
- 对于糖尿病和糖尿病前期患者,建议定期监测CVAI,以减轻中风风险.
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