肠道中早期生命微生物的继承遵循全球人类的共同模式
Guilherme Fahur Bottino1, Kevin S Bonham1, Fadheela Patel2
1Department of Biological Sciences, Wellesley College, Wellesley, MA, USA.
Nature communications
|January 14, 2025
概括
科学家们开发了一种模型,使用肠道微生物组数据估计婴儿年龄,揭示了普遍的发育模式. 这种"微生物组年龄"工具有助于评估早期肠道成熟和儿童发育.
科学领域:
- 微生物学 微生物学
- 发育生物学 发展生物学
- 生物信息学是一种生物信息学.
背景情况:
- 了解婴儿肠道微生物组的动态对于儿童健康至关重要.
- 现有的规范模型没有准确地追踪早期肠道微生物的发展.
研究的目的:
- 开发婴儿肠道微生物组成熟的规范模型.
- 用高时间分辨率的微生物分类学数据估计婴儿年龄.
主要方法:
- 在全球1827名婴儿的3154个元基因组样本上训练了一种随机森林模型.
- 利用肠道微生物的分类学相对丰度来预测儿童的年龄.
- 分析了关键的分类学预测因素和功能基因趋势.
主要成果:
- 在年龄估计中达到2.56个月的根平均平方误差.
- 确定了关键的微生物转变,包括减少Bifidobacterium spp. 并且增加了Faecalibacterium prausnitzii的数量.
- 在不同种群中展示了保存的微生物继承模式,表明了普遍的发育轨迹.
结论:
- 开发的模型提供了一个可靠的可靠模型.
- 微生物群年龄 微生物群年龄
- 评估早期肠道成熟的基准.
- 婴儿肠道中的微生物继承遵循了保守的,普遍的发育途径.
- 这种工具可以补充现有的儿童发展措施.
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