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The Supercomplexes in the Crista Membrane01:41

The Supercomplexes in the Crista Membrane

2.5K
The mitochondrial cristae membrane is the primary site for the oxidative phosphorylation (OXPHOS) process of energy conversion mediated through respiratory complexes I to V. These complexes have been widely studied for decades, and it has been proven that they form supramolecular structures called respiratory supercomplexes (SC). These higher-order complexes may be crucial in maintaining the biochemical structure and improving the physiological activity of the individual complexes while...
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Tension Response at Adherens Junctions01:26

Tension Response at Adherens Junctions

2.6K
The adherens junctions that anchor cells together are multi-protein complexes that dynamically adapt to mechanical stimuli such as tensile forces and shear stress. Mechanosensory proteins in these junctions can sense such mechanical stimuli and undergo a shift in their conformation, resulting in an altered function — a process called mechanotransduction.
α-Catenin as a Mechanosensory Protein
The α-catenin of adherens junctions is an allosteric protein with three VH (vinculin...
2.6K
Adherens Junctions01:24

Adherens Junctions

4.7K
Strong contact points between adjacent cells anchor them to each other, forming tissues. Such anchoring junctions are of two types –  adherens junctions and desmosomes. Adherens junctions are abundant in tissues such as  epithelium and endothelium, forming a continuous zone of adhesion called the adhesion belt. In other tissues, such as  heart muscle, they appear as clusters, linking the cells to produce coordinated heart muscle contraction.
Adherens Junctions are Dynamic
4.7K
Electron Transport Chain: Complex III and IV01:43

Electron Transport Chain: Complex III and IV

7.0K
During the electron transport chain, electrons from NADH and FADH2 are first transferred to complexes I and II, respectively. These two complexes then transfer the electrons to ubiquinol, which carries them further to complex III. Complex III passes the electrons across the intermembrane space to Cyt c, which carries them further to complex IV. Complex IV donates electrons to oxygen and reduces it to water. As electrons pass through complexes I, III, and IV, the energy released aids the pumping...
7.0K
Oxidation and Reduction of Organic Molecules01:19

Oxidation and Reduction of Organic Molecules

6.1K
Energy production within a cell involves many coordinated chemical pathways. Most of these pathways are combinations of oxidation and reduction reactions, which occur at the same time. An oxidation reaction strips an electron from an atom in a compound, and the addition of this electron to another compound is a reduction reaction. Because oxidation and reduction usually occur together, these pairs of reactions are called redox reactions.
The removal of an electron from a molecule, results in a...
6.1K
Anchoring Junctions01:03

Anchoring Junctions

3.6K
Anchoring junctions are multiprotein complexes that help cells connect to other cells and the extracellular matrix. Anchoring junctions are present on the lateral and basal surfaces of cells, providing strong and flexible connections. Focal adhesions are often formed due to cell interactions with the ECM substrata, which initiate signal transduction via kinase cascades and other mechanisms. Together, they provide stability and tissue integrity. There are three types of anchoring junctions:...
3.6K

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相关实验视频

Updated: Jun 2, 2025

Using Cell-substrate Impedance and Live Cell Imaging to Measure Real-time Changes in Cellular Adhesion and De-adhesion Induced by Matrix Modification
09:11

Using Cell-substrate Impedance and Live Cell Imaging to Measure Real-time Changes in Cellular Adhesion and De-adhesion Induced by Matrix Modification

Published on: February 19, 2015

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在贝粘附中进行catechol氧化还原维护.

Stephanie X Wang1, J Herbert Waite2,3

  • 1Department of Chemistry & Biochemistry, University of California Santa Barbara, Santa Barbara, CA, USA.

Nature reviews. Chemistry
|January 14, 2025
PubMed
概括

贝类使用氧化还原储库来保护粘合剂甲基醇免受氧化. 模仿这些天然的抗氧化策略可以提高合成生物材料的长期稳定性.

科学领域:

  • 生物材料科学 生物材料科学
  • 粘附科学 粘附科学 粘附科学
  • 海洋生物学 海洋生物学

背景情况:

  • 以贝类为灵感的教化材料在水下具有出色的粘附性,但遭受氧化.
  • 贝类拥有天然的氧化还原储备,以保持它们的粘合蛋白中的甲基醇稳定性.
  • 了解这些自然机制是开发耐用合成粘合剂的关键.

研究的目的:

  • 为了研究贝粘合蛋白中的抗氧化机制.
  • 探索模仿贝的氧化还原策略对合成生物材料的潜力.
  • 增强基于甲基醇的粘合剂的长期性能和稳定性.

主要方法:

  • 对贝的"核心"架构进行分析.
  • 通过富含甲基醇和富含醇的中间层研究氧化还原平衡.
  • 研究金属离子复合体在稳定catechol相互作用中的作用.

主要成果:

  • 贝类的粘合蛋白利用氧化还原来修复氧化过的甲基醇 (quinones).
  • 一个"核心外"结构保护贝,具有专门的中间层用于氧化还原平衡.
  • 氧化还原的耗尽导致涂层损坏和核心暴露.

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Resin-Assisted Capture Coupled with Isobaric Tandem Mass Tag Labeling for Multiplexed Quantification of Protein Thiol Oxidation
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Resin-Assisted Capture Coupled with Isobaric Tandem Mass Tag Labeling for Multiplexed Quantification of Protein Thiol Oxidation

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Analyzing Cell Surface Adhesion Remodeling in Response to Mechanical Tension Using Magnetic Beads
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Analyzing Cell Surface Adhesion Remodeling in Response to Mechanical Tension Using Magnetic Beads

Published on: March 8, 2017

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相关实验视频

Last Updated: Jun 2, 2025

Using Cell-substrate Impedance and Live Cell Imaging to Measure Real-time Changes in Cellular Adhesion and De-adhesion Induced by Matrix Modification
09:11

Using Cell-substrate Impedance and Live Cell Imaging to Measure Real-time Changes in Cellular Adhesion and De-adhesion Induced by Matrix Modification

Published on: February 19, 2015

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Resin-Assisted Capture Coupled with Isobaric Tandem Mass Tag Labeling for Multiplexed Quantification of Protein Thiol Oxidation
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Resin-Assisted Capture Coupled with Isobaric Tandem Mass Tag Labeling for Multiplexed Quantification of Protein Thiol Oxidation

Published on: June 21, 2021

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Analyzing Cell Surface Adhesion Remodeling in Response to Mechanical Tension Using Magnetic Beads
07:55

Analyzing Cell Surface Adhesion Remodeling in Response to Mechanical Tension Using Magnetic Beads

Published on: March 8, 2017

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结论:

  • 以自然为灵感的抗氧化策略对于长期持久的基于甲基醇的粘合剂至关重要.
  • 翻译贝的氧化还原稳态可以导致更可持续和更强大的合成聚合物粘合剂.
  • 对这些机制的进一步研究将推动水下粘附技术领域的发展.