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Updated: Jun 2, 2025

Mapping Alzheimer's Disease Variants to Their Target Genes Using Computational Analysis of Chromatin Configuration
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Mapping Alzheimer's Disease Variants to Their Target Genes Using Computational Analysis of Chromatin Configuration

Published on: January 9, 2020

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多原子定量特征位置链接串联重复大小变异与人类大脑中的基因调节

Ya Cui1, Frederick J Arnold2, Jason Sheng Li3

  • 1Division of Computational Biomedicine, Department of Biological Chemistry, University of California, Irvine, Irvine, CA, USA. yac7@uci.edu.

Nature genetics
|January 14, 2025
PubMed
概括

串联重复 (TR) 大小变化影响大脑基因调节和神经疾病风险. 这项研究绘制了数以百万计的TR分子定量特征位点 (TR-xQTLs),揭示了TRs是脑疾病的潜在因果变体.

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