纽约市的社会脆弱性和生物衰老:基于电子健康记录的研究
Pablo Knobel1, Elena Colicino2, Itai Kloog2
1Department of Environmental Medicine and Climate Science, Icahn School of Medicine at Mount Sinai, 1 Gustave L. Levy Place, Box 1057, New York, NY, 10029, USA. pablo.knobel@mssm.edu.
概括
社会脆弱性,特别是社会经济地位,加快了生物衰老 (表型衰老加速). 这增加了健康风险,特别是妇女和少数群体,突出了社会决定因素对衰老的影响.
科学领域:
- 老年学是一门学科.
- 公共卫生 公共卫生
- 社会流行病学 社会流行病学
背景情况:
- 由于不同的衰老轨迹,时间学年龄是健康结果的不充分预测因素.
- 现型年龄加速 (PhenoAgeAccel) 使用临床生物标志物提供了更准确的生物年龄测量.
- 环境因素和社会决定因素显著影响健康的衰老.
研究的目的:
- 调查社会脆弱性指数 (SVI) 主题与PhenoAgeAccel之间的关联.
- 评估SVI对生物衰老的综合和差异性影响.
- 检查对弱势人口群体的影响.
主要方法:
- 利用了31,913名患者 (2011-2022) 的电子健康记录.
- 计算PhenoAgeAccel作为PhenoAge (基于生物标志物) 和时间年龄之间的差异.
- 分析了四个SVI主题 (社会经济地位,家庭组成,少数群体地位,住房/交通) 与PhenoAgeAccel的关联.
主要成果:
- 在SVI混合物的十分之一增加与PhenoAgeAccel的0.23年增加相关.
- 社会经济地位是主要的驱动因素,占SVI协会的61%.
- 对妇女和种族/少数民族来说,有害影响更为明显.
结论:
- 社区层面的社会脆弱性显著加快了居民的生物年龄.
- 这种加速与增加的发病率和死亡率风险有关.
- 社会经济地位在调解社会环境对衰老的负面影响方面发挥着至关重要的作用.
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