瘤透性血细胞是阴茎状细胞癌的预后因素
P J Stenzel1,2, A Thomas3, M Schindeldecker4
1Institute of Pathology, University Medical Center Mainz, Langenbeckstr. 1, 55131, Mainz, Germany. pstenzel@med.uni-frankfurt.de.
Virchows Archiv : an international journal of pathology
|January 14, 2025
概括
这项研究表明,瘤微环境中的特定免疫细胞,特别是血细胞,与阴茎癌 (PeCa) 患者的更好的生存结果有关. 这些发现突出了这种罕见疾病的潜在新预后标志物.
科学领域:
- 在瘤学瘤学.
- 免疫学 免疫学 免疫学
- 病理学 病理学 病理学
背景情况:
- 阴茎癌 (PeCa) 的预后很差,特别是在转移阶段,有效治疗和生存预测因素有限.
- 描述瘤微环境 (TME) 对于确定PeCa.的预后目标至关重要.
研究的目的:
- 调查瘤透免疫细胞和PD-L1表达在阴茎癌的TME的预后意义.
- 确定PeCa患者的整体存活率 (OS) 和无复发存活率 (RFS) 的强有力的预测因素.
主要方法:
- 使用组织微阵列和免疫组织化学分析了93名PeCa患者的队列,用于各种免疫细胞标记物 (CD3,CD4,CD8,CD20,CD56,CD138,FoxP3) 和PD-L1.1.
- 数字图像分析量化了免疫细胞的存在和分布;PD-L1使用综合阳性评分 (CPS) 获得得分.
- 进行了单变体和多变体生存分析,以评估免疫细胞和PD-L1与患者结局的关联.
主要成果:
- 在PeCa样本中经常检测到T细胞,B细胞和血细胞等免疫细胞. 大约50%的样本显示PD-L1阳性.
- 在单变量分析中,高PD-L1 CPS,血细胞,细胞毒性T细胞 (CTLs) 和B细胞与有利的OS有关.
- 在多变量分析中,血细胞仍然是有利的OS (p=0.04) 的重要独立预测因子.
结论:
- 在TME内的免疫细胞组成,特别是血细胞,显示出与阴茎癌患者存活率的良好关联.
- 这些发现表明,血细胞可以作为重要的预后因素,并可能预测对PeCa的免疫治疗反应.
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