鼻癌和耐药性之间的一个渔网:竞争的内源性RNA网络
Mingtai Li1, Tongtong Mo1, Zisha Yang2
1Second School of Clinical Medicine, Guangdong Medical University, Dongguan, 523808, Guangdong Province, China.
Current treatment options in oncology
|January 14, 2025
概括
鼻癌 (NPC) 中的化疗/放射治疗耐药性是一个主要的挑战. 竞争的内源RNA网络 (ceRNETs) 为克服这种抵抗提供了潜在的见解和治疗目标.
科学领域:
- 在瘤学瘤学.
- 分子生物学分子生物学
- 遗传学 是一个遗传学.
背景情况:
- 鼻癌 (NPC) 治疗依赖于化疗和放射治疗,但耐药性限制了疗效.
- 在NPC中,化疗/放射治疗耐药性是改善患者治疗结果的重要障碍.
- 竞争的内源RNA网络 (ceRNETs) 正在成为癌症治疗耐药性的关键调节者.
研究的目的:
- 审查ceRNA网络在NPC中调节化疗/放射治疗耐药性的分子机制.
- 探索各种ceRNA分子 (circRNA,lncRNA,miRNA) 在NPC耐药性中的作用.
- 讨论ceRNAs作为NPC耐药性的预后指标和治疗点的潜力.
主要方法:
- 文献综述侧重于研究研究ceRNA网络和NPC中的化疗/放射治疗耐药性.
- 在ceRNET中分析涉及循环RNA,长非编码RNA和microRNA的分子机制.
- 关于ceRNA介导的耐药性途径的当前理解的综合.
主要成果:
- 包含circRNA,lncRNA和miRNA的ceRNA网络在NPC中介化疗/放射治疗耐药性方面发挥着至关重要的作用.
- 特定的ceRNA相互作用可以促进或抑制NPC细胞对治疗的敏感性.
- ceRNA网络的失调有助于治疗耐药性的发展.
结论:
- ceRNA网络代表了一个复杂的调节系统,是NPC中化学/放射治疗耐药性的基础.
- 准ceRNA通路对开发新型治疗策略来克服耐药性充满希望.
- ceRNA分子可以作为预测NPC患者治疗反应和预后的有价值的生物标志物.
相关概念视频
siRNA - Small Interfering RNAs
16.5K
Small interfering RNAs, or siRNAs, are short regulatory RNA molecules that can silence genes post-transcriptionally, as well as the transcriptional level in some cases. siRNAs are important for protecting cells against viral infections and silencing transposable genetic elements.
In the cytoplasm, siRNA is processed from a double-stranded RNA, which comes from either endogenous DNA transcription or exogenous sources like a virus. This double-stranded RNA is then cleaved by the...
In the cytoplasm, siRNA is processed from a double-stranded RNA, which comes from either endogenous DNA transcription or exogenous sources like a virus. This double-stranded RNA is then cleaved by the...
16.5K
lncRNA - Long Non-coding RNAs
8.5K
In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...
8.5K
RNA Interference
25.9K
RNA interference (RNAi) is a process in which a small non-coding RNA molecule blocks the post-transcriptional expression of a gene by binding to its messenger RNA (mRNA) and preventing the protein from being translated.
This process occurs naturally in cells, often through the activity of genomically-encoded microRNAs. Researchers can take advantage of this mechanism by introducing synthetic RNAs to deactivate specific genes for research or therapeutic purposes. For example, RNAi could be used...
This process occurs naturally in cells, often through the activity of genomically-encoded microRNAs. Researchers can take advantage of this mechanism by introducing synthetic RNAs to deactivate specific genes for research or therapeutic purposes. For example, RNAi could be used...
25.9K
MicroRNAs
3.0K
MicroRNA (miRNA) are short, regulatory RNA transcribed from introns (non-coding regions of a gene) or intergenic regions (stretches of DNA present between genes). Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself, forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA...
3.0K
Experimental RNAi
6.0K
RNA interference (RNAi) is a cellular mechanism that inhibits gene expression by suppressing its transcription or activating the RNA degradation process. The mechanism was discovered by Andrew Fire and Craig Mello in 1998 in plants. Today, it is observed in almost all eukaryotes, including protozoa, flies, nematodes, insects, parasites, and mammals. This precise cellular mechanism of gene silencing has been developed into a technique that provides an efficient way to identify and determine the...
6.0K
The Nucleolus
8.7K
The nucleolus is the most prominent substructure of the nucleus. When it was first discovered, it was considered to be an isolated organelle that forms fibrils and granules. In 1931, the relationship between the nucleolus and chromosomes was first described by Heitz. He observed that the appearance and size of nucleolus varies depending on the stage of the cell cycle. He also noticed constricted regions on different chromosomes clustered together at definite cell cycle stages. These regions,...
8.7K


