中性蛋白与高密度脂蛋白胆固醇比率和胆结石之间的关联:一个横截面研究
Yinkang Wang1,2, Xingchen Shang1,2, Yinchao Zhang1,2
1Department of General Surgery, The Affiliated Wuxi People's Hospital of Nanjing Medical University, Wuxi, China.
中性粒细胞与高密度脂蛋白胆固醇 (NHR) 的比率显示出与美国成年人胆结石风险增加的近线性关联. 虽然NHR有一定的预测价值,但与其他标记物相比,它的力量很弱.
科学领域:
- 生物化学 生物化学
- 流行病学 流行病学
- 临床医学 临床医学
背景情况:
- 胆固醇与胆结石的联系已经得到了很好的证实.
- 高密度脂蛋白胆固醇 (HDL-C) 是一种重要的脂质标记物.
- 中性粒细胞与HDL-C比率 (NHR) 是一个新兴的生物标志物.
研究的目的:
- 调查美国成年人中NHR和胆结石患病率之间的关联.
- 评估NHR对胆结石风险的预测能力.
主要方法:
- 利用了2017-2020年国家健康和营养检查调查 (NHANES) 数据.
- 通过将中性粒细胞计数除以HDL-C计算NHR.
- 采用后勤回归,受限立方线和ROC曲线分析.
主要成果:
- 在NHR和胆结石之间发现了显著的积极关联 (OR=1.05,95%CI:1.01-1.10).
- 确定NHR和胆结石之间的关系是近线性的.
- 根据ROC分析,NHR对于胆结石发育具有预测值 (AUC=0.550).
结论:
- 在近线的方式中,NHR与增加胆结石易感性有关.
- 虽然NHR显示胆结石风险的预测值较弱,但具有预测价值.
- 需要进一步的前性研究来验证NHR在胆结石病原发生中的作用.
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