相对脂肪量与喘的关联:炎症标志物作为潜在的调解者
Meicen Zhou1,2, Ting Zhang1,2, Ziyi Zeng1,2
1Department of Pediatrics, West China Second University Hospital, Sichuan University, No. 20, Section 3, South Renmin Road, Chengdu, Sichuan Province, 610041, China.
Lipids in health and disease
|January 14, 2025
概括
较高的相对脂肪量 (RFM) 与喘风险增加有关. 通过SII和SIRI测量的全身炎症部分解释了这种联系,特别是在当前的喘病例中.
科学领域:
- 公共卫生 公共卫生
- 流行病学 流行病学
- 生物统计学 生物统计学
背景情况:
- 肥胖及其与喘等慢性呼吸道疾病的关系是严重的公共卫生问题.
- 相对脂肪量 (RFM) 是一种新兴的肥胖度量,与传统的BMI不同.
- 系统性炎症在RFM-喘关系中的作用需要进一步阐明.
研究的目的:
- 调查相对脂肪量 (RFM) 与喘患病率之间的关联.
- 检查系统免疫炎症指数 (SII) 和系统炎症反应指数 (SIRI) 在这个协会中的潜在调解作用.
主要方法:
- 国家健康和营养检查调查 (NHANES) 数据 (2007-2018) 的横截面分析.
- 用多变量逻辑回归,受限立方线和子组分析来评估RFM-喘相关性.
- 调解分析探讨了SII和SIRI的角色,使用灵敏度分析和倾向性得分匹配 (PSM) 来确定稳定性.
主要成果:
- 在更高的RFM和喘患病率之间观察到一个积极的关联,转折点在34.08.
- 这种关联在转折点 (OR 1.05) 上方比在转折点 (OR 1.02) 下方更强烈,并且在各个子组中一致.
- SII和SIRI分别部分调解了7.48%和3.88%的RFM-喘联系;PSM后的发现是强大的.
结论:
- 相对脂肪量与美国人口中喘患病率有积极联系.
- 由SII和SIRI表示的全身炎症,部分介于RFM和喘之间的关系.
- 这些发现强调了身体组成和炎症在喘病原发生的重要性,特别是在目前喘患者中.
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