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Updated: Jun 2, 2025

Optogenetic Phase Transition of TDP-43 in Spinal Motor Neurons of Zebrafish Larvae
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在ALS/FTLD的rNLS8小鼠模型中,替代性3' UTR多化被破坏

Randall J Eck1,2, Paul N Valdmanis3,4, Nicole F Liachko2,5

  • 1Graduate Program in Neuroscience, University of Washington, Seattle, WA, 98195, USA.

Molecular brain
|January 14, 2025
PubMed
概括

替代性多化在肌缩性侧面硬化 (ALS) 和前叶退化与TDP-43病理 (FTLD-TDP) 中被破坏. rNLS8小鼠模型显示了这些变化,为神经退行机制提供了洞察力.

关键词:
这就是ALS.替代性的多基解.这是一个FTLD.在TDP-43中使用.

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