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Updated: Jun 12, 2026

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Drug Repurposing Hypothesis Generation Using the "RE:fine Drugs" System
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药剂师在缓解外科期间药物错误中的作用:系统性审查
Lina Naseralallah1, Somaya Koraysh2, May Alasmar2
1Pharmacy Department, Hamad Medical Corporation, Doha, Qatar. LNaseralallah@hamad.qa.
Systematic reviews
|January 14, 2025
概括
在外科手术前的药剂师干预显示出减少药物错误的前景. 然而,目前的证据受限于低质量的研究,需要进一步高质量的研究才能得出最终的结论.
科学领域:
- 药房 药房 药房 药房
- 患者安全 患者安全
- 麻醉学 麻醉学
背景情况:
- 药物错误是全球重要的健康问题,特别是在复杂的外科环境中.
- 术后护理的动态性和高警觉药物的使用增加了错误的风险.
- 药剂师拥有通过有针对性的干预来减轻这些风险的专业知识.
研究的目的:
- 综合当前关于药剂师干预措施在减少术后环境中的药物错误方面的有效性证据.
- 评估药剂师在手术过程中提高药物安全性的作用和影响.
主要方法:
- 对来自PubMed,CINAHL和Embase的研究进行了系统审查 (从开始到2023年9月).
- 包括的研究重点是药剂师主导的干预措施,以减少成人外科手术期间的药物错误.
- 通过Crowe批判性评估工具评估研究质量,并使用DEPICT-2合成数据.
主要成果:
- 十六项研究符合纳入标准,主要包括多组分干预措施,如药物调和和工作人员教育.
- 药剂师干预通常与整体药物错误率的降低有关,尽管对特定错误亚型的发现不一致.
- 药物优化,包括保持或切换药物,是观察到的最常见的干预措施.
结论:
- 现有证据表明,药剂师主导的干预措施对外科手术期间的药物安全性产生了积极影响.
- 目前的证据基础以低质量和不足的数量为特征,研究设计和错误报告具有显著的异质性.
- 具有严格控制和明确定义的高质量研究对于确认这些干预措施的好处至关重要.
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