全谷物食品消费与肺癌风险的关联:一项前性队列研究
Kanran Wang1,2, Junhan Zhao3,4, Dingyi Yang5,6
1Radiation Oncology Center, Chongqing University Cancer Hospital, Chongqing, 400030, China. kankans93@163.com.
Cancer cell international
|January 14, 2025
概括
消费全谷物食品与患肺癌的风险降低有关,特别是非小细胞肺癌 (NSCLC). 这项大型研究表明,全谷物对肺癌发病率有保护作用.
科学领域:
- 流行病学 流行病学
- 营养科学 营养科学
- 在瘤学瘤学.
背景情况:
- 关于全谷物食品摄入量和预防肺癌的流行病学证据有限.
- 公共卫生倡议需要关于饮食和癌症风险的可靠数据.
研究的目的:
- 调查全谷物食品消费与肺癌风险之间的关联.
- 利用前列腺,肺,结肠直肠和卵巢癌查试验 (PLCO) 队列的数据.
主要方法:
- 用自行管理的饮食史问卷 (DHQ) 评估饮食摄入量.
- 事件肺癌病例被病理验证.
- 考克斯比例危险回归用于估计危险比率和置信区间.
主要成果:
- 在12.2年的中位数随访期间,共记录了1706例肺癌事件.
- 最高和最低的全谷物消费季度显示,肺癌风险降低了16% (HR 0.84),NSCLC风险降低了17% (HR 0.83).
- 对于小细胞肺癌 (SCLC) 没有发现显著的关联. 观察到一个线性剂量反应模式.
结论:
- 全谷物食品的消费与肺癌和NSCLC的风险降低有关.
- 研究结果表明,全谷物在预防肺癌方面具有潜在的保护作用.
- 进一步的研究可以探索这种关联背后的机制.
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