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在SARS-CoV-2-阳性年轻人中,NRF2抗氧化反应和干扰素刺激基因的表达方式不同

Walter Toscanelli¹, Matteo Fracella², Marta De Angelis^1,2

¹Laboratory Affiliated to Istituto Pasteur Italia-Fondazione Cenci Bolognetti, Department of Public Health and Infectious Diseases, Sapienza University, Rome, Italy.

Immunity, inflammation and disease

|January 15, 2025

概括

儿童严重急性呼吸系统综合征-冠状病毒-2 (SARS-CoV-2) 感染会降低核因子-E2相关因子-2 (NRF2) 抗氧化反应. 这种减少与干扰素 (IFN) 途径激活增加相关,这表明NRF2与免疫之间存在联系.

科学领域:

免疫学免疫学免疫学
病毒学病毒学
分子生物学分子生物学

背景情况:

像SARS-CoV-2这样的呼吸系统病毒可以抑制NRF2抗氧化反应,从而产生氧化应激.
NRF2通过抑制干扰素 (IFN) 途径来调节先天免疫反应.
对于NRF2的调节及其与SARS-CoV-2感染的年轻个体的IFN反应的联系,需要进一步调查.

研究的目的:

调查与SARS-CoV-2儿童的NRF2和氧化还原相关基因的表达.
分析NRF2表达与小儿SARS-CoV-2病例中的I型和III型IFN反应之间的相关性.
探索NRF2调节,IFN通路和儿童临床症状之间的关系.

主要方法:

在接受SARS-CoV-2检测的儿童的鼻抽样中检查了NRF2和氧化还原相关基因表达.
基于SARS-CoV-2阳性,年龄和症状存在的分层表达分析.
与I/III型IFN基因和IFN刺激基因 (ISG) 相关联的基因表达.

主要成果:

与负面儿童相比,SARS-CoV-2阳性儿童的NRF2表达显著较低.
较低的NRF2水平与IFNα2,IFNλ3,ISG15和ISG56.6的表达增加相关.
患有厌氧症/老年症的症状儿童表现出APE1,I型IFN,ISG56和NLRP3.3的表达升高.

结论:

在年轻人中,SARS-CoV-2感染涉及NRF2抗氧化途径和IFN介导的免疫反应之间的相互依赖.
这些发现突出了SARS-CoV-2影响儿童先天免疫力的潜在机制.
对NRF2调节的进一步研究可能为儿科病毒感染提供治疗见解.

关键词:

在APE-1中,APE-1被认为是APE-1.对干扰素的反应这就是NRF2的NRF2.在SARS-CoV-2中.抗氧化剂反应的抗氧化剂反应一些炎症一些炎症

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