2型糖尿病的变化和MASLD/相关的SLD状态的变化与患心血管疾病的风险相关
Yasuhiro Matsubayashi1, Kazuya Fujihara1, Laymon Khin1
1Department of Hematology, Endocrinology and Metabolism, Faculty of Medicine, Niigata University, Niigata, Japan.
Diabetes, obesity & metabolism
|January 15, 2025
概括
2型糖尿病 (DM) 和与代谢功能障碍相关的脂肪性肝病 (MASLD) 的缓解显著降低了心血管疾病 (CVD) 的风险. 在这两种情况中实现缓解提供了最大的心血管疾病风险降低.
科学领域:
- 心脏病学 心脏病学
- 肝病学 肝病学是一种肝病学.
- 内分泌学 在内分泌学.
背景情况:
- 与代谢功能障碍相关的脂肪性肝病 (MASLD) 和2型糖尿病 (DM) 是普遍存在的疾病,通常是并存的.
- 无论是MASLD还是DM,都独立地与心血管疾病 (CVD) 的风险增加有关.
- 这些疾病的缓解对后续心血管疾病风险的影响需要进一步调查.
研究的目的:
- 评估2型糖尿病 (DM) 或与代谢功能障碍相关的脂肪性肝病 (MASLD) /相关的SLD (r-SLD) 缓解与患心血管疾病 (CVD) 的风险之间的关联.
主要方法:
- 利用来自日本全国索赔数据库 (基线和2年后续) 的健康检查数据.
- 包括9345名患有DM相关的MASLD/r-SLD和71,932名患有非DM的MASLD/r-SLD的参与者,随访时间至少为3年.
- 根据MASLD/r-SLD或DM的缓解状态分层参与者,使用多变量Cox比例危险模型分析新发性心血管疾病风险.
主要成果:
- 在平均4.9年的随访期间,观察到1368例心血管疾病病例.
- 脑膜炎的缓解与50%降低心血管疾病风险相关 (HR 0.50).
- MASLD/r-SLD的缓解与35%的心血管疾病风险降低有关 (HR 0.65),这两种疾病的缓解都显示66%的降低 (HR 0.34).
- 在没有DM的参与者中,MASLD/r-SLD缓解并没有显著降低心血管疾病风险.
结论:
- MASLD/r-SLD缓解对心血管疾病风险的影响受到DM存在或不存在的显著影响.
- 在患有DM和MASLD/r-SLD同时存在的患者中,实现MASLD/r-SLD缓解可以显著降低心血管疾病风险,相当于DM缓解.
- 这些发现强调了管理这两种疾病的重要性,以减少受影响个体的心血管风险.
相关概念视频
Diabetes Mellitus: Type 2 and Gestational
2.2K
Type 2 diabetes, characterized by insulin resistance, arises when the insulin receptors on cells lose responsiveness to insulin, diminishing the cell's capacity to take up glucose, resulting in elevated blood glucose levels. To receive a diagnosis of Type 2 diabetes, a series of blood glucose tests are necessary to assess whether the blood glucose falls within normal parameters. If the result is out of the normal range, a patient may be diagnosed as prediabetic or diabetic, depending on the...
2.2K
Carbohydrate Metabolism
10.8K
Carbohydrates are polymers composed of molecules containing atoms of carbon, hydrogen and oxygen. One gram of carbohydrate can provide four kilo-calories of energy, which makes it the most efficient instant energy source.
Starch accounts for approximately 60% of the carbohydrates consumed by humans. Since amylase enzymes cannot function in the stomach's acidic environment, starch can only be digested in the mouth and small intestine. Simple sugars are found naturally in milk and fruits in...
Starch accounts for approximately 60% of the carbohydrates consumed by humans. Since amylase enzymes cannot function in the stomach's acidic environment, starch can only be digested in the mouth and small intestine. Simple sugars are found naturally in milk and fruits in...
10.8K
Diabetes: Symptoms, Diagnosis, and Complications
500
For most patients, experiencing several weeks of polyuria, polydipsia, fatigue, and significant weight loss may indicate the presence of diabetes. Furthermore, adults displaying the phenotypic appearance of type 2 diabetes (particularly those who are obese and not initially insulin-requiring), may have islet cell autoantibodies, suggesting autoimmune-mediated β cell destruction and a diagnosis of latent autoimmune diabetes of adults (LADA). The categorization of glucose homeostasis is...
500
Overview of Lipid Metabolism
997
Lipid metabolism is a crucial process in the human body that involves the synthesis and degradation of lipids. This process is essential for energy production, cell membrane formation, and hormone production, among other functions.
Lipolysis: The Breakdown of Lipids:
Lipolysis is the process of breaking down lipids, particularly triglycerides, into glycerol and fatty acids. This process typically occurs in the adipose tissue and is triggered by various hormones, including glucagon and...
Lipolysis: The Breakdown of Lipids:
Lipolysis is the process of breaking down lipids, particularly triglycerides, into glycerol and fatty acids. This process typically occurs in the adipose tissue and is triggered by various hormones, including glucagon and...
997
Pathophysiology of Diabetes
859
Diabetes mellitus is a chronic metabolic disorder characterized by hyperglycemia. The four categories of diabetes are type 1 diabetes, type 2 diabetes, other specific types of diabetes, and gestational diabetes.
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,...
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,...
859
Psychoneuroimmunology: Diabetes and Cancer
22
Chronic stress has been linked to both the onset and progression of serious health conditions, including Type 2 diabetes and cancer. Type 2 diabetes, a widespread chronic illness, is closely associated with obesity and insulin resistance, both of which often worsen under stress. Studies indicate that men experiencing high levels of chronic stress face a 45% higher risk of developing diabetes compared to those with minimal stress. Stress triggers physiological responses that elevate blood...
22


