基线和累积的中国内脏脂肪指数和糖尿病病:一项前性队列研究
Ming Sun1, Qitong Liu1, Yang Liu1
1Key Laboratory of Environmental Stress and Chronic Disease Control & Prevention, Ministry of Education, Department of Biostatistics and Epidemiology, School of Public Health, China Medical University, Shenyang, China.
Diabetes, obesity & metabolism
|January 15, 2025
概括
较高的中国内脏脂肪指数 (CVAI) 水平与糖尿病病 (DKD) 风险增加有关. 保持较低的CVAI可能有利于糖尿病患者,需要定期监测.
科学领域:
- 内分泌学 在内分泌学.
- 腎臟病學 (nephrology) 是一種醫學.
- 心血管健康 心血管健康
背景情况:
- 糖尿病病 (DKD) 是糖尿病的一个主要并发症,占慢性病病例的近一半.
- 在糖尿病人群中,DKD对糖尿病人群的死亡率有显著的贡献.
- 中国纵向内脏脂肪指数 (CVAI) 和DKD之间的关联仍未得到充分研究.
研究的目的:
- 为了研究基线和累积的中国内脏脂肪指数 (CVAI) 和糖尿病病 (DKD) 在糖尿病队列中的发病率之间的关系.
- 评估CVAI在DKD发展中的预测价值.
主要方法:
- 一项前性队列研究,涉及Kailuan研究中的7874名糖尿病患者.
- 连续的CVAI记录来自对腰围,BMI,甘油三和高密度胆固醇的重复测量.
- 考克斯比例危险回归模型被用于分析CVAI和DKD发病率之间的关联,由蛋白尿或降低EGFR定义.
主要成果:
- 在基线和累积CVAI水平和DKD发病率之间观察到显著的积极关联 (p < 0.001).
- 较高的基线CVAI增加了DKD风险 (HR:1.24,95%CI:1.09-1.42).
- 高累积CVAI显示了与DKD风险的较强正相关性 (HR: 1.62,95%CI: 1.29-2.04).
结论:
- 升高的基线和累积CVAI独立地与患糖尿病病的风险增加有关.
- 这些发现强调了维持糖尿病患者CVAI水平较低的重要性.
- 建议糖尿病患者定期监测CVAI,以减轻DKD风险.
更多相关视频
相关概念视频
External Anatomy of the Kidney
723
The kidneys are a pair of bean-shaped organs in the human body that play a critical role in maintaining overall health. They filter out waste products from the blood, regulate blood pressure, maintain electrolyte balance, and stimulate the production of red blood cells.
The kidneys are located in the retroperitoneal space on either side of the vertebral column, protected posteriorly by the 11th and 12th ribs. The right kidney sits slightly lower than the left owing to the presence of the liver...
The kidneys are located in the retroperitoneal space on either side of the vertebral column, protected posteriorly by the 11th and 12th ribs. The right kidney sits slightly lower than the left owing to the presence of the liver...
723
Diabetes: Symptoms, Diagnosis, and Complications
500
For most patients, experiencing several weeks of polyuria, polydipsia, fatigue, and significant weight loss may indicate the presence of diabetes. Furthermore, adults displaying the phenotypic appearance of type 2 diabetes (particularly those who are obese and not initially insulin-requiring), may have islet cell autoantibodies, suggesting autoimmune-mediated β cell destruction and a diagnosis of latent autoimmune diabetes of adults (LADA). The categorization of glucose homeostasis is...
500


