与其他CKD病因相比,狼性炎的长期结果
Charikleia Chrysostomou1,2, Francesca Faustini1, Iva Gunnarsson1
1Division of Rheumatology, Department of Medicine-Solna, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden.
Kidney international reports
|January 15, 2025
概括
与原发性淋巴细胞疾病 (PGD) -CKD相比,狼性炎 (LN) -CKD患者面临更高的死亡和心血管事件风险. 然而,他们的置换疗法 (KRT) 的风险较低,类似于其他CKD原因.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 心脏病学 心脏病学
- 免疫学 免疫学 免疫学
背景情况:
- 慢性病 (CKD) 包含各种病因,每个病因都可能对心血管和的结果产生不同的影响.
- 狼性炎 (LN) 是CKD的自身免疫性原因,但其与其他CKD类型相比,关于心血管事件和功能下降的长期预后尚未确立.
研究的目的:
- 为了比较患有LN-CKD患者和患有CKD患者之间的长期心血管和结局,这些患者患有由原发性淋巴细胞疾病 (PGD) 或其他原因 (其他-CKD) 引起的CKD.
主要方法:
- 一项瑞典脏注册研究 (2006-2021) 将LN-CKD (n=317) 与PGD-CKD (n=2296) 和其他CKD (n=34,778) 的结果进行了比较.
- 考克斯比例危险模型用于估计死亡率,主要心血管不良事件 (MACE) 和置换疗法 (KRT) 的调整危险比率 (HRs).
主要成果:
- 在其他CKD和PGD-CKD组之间,LN-CKD患者的绝对死亡和MACE风险中介.
- 5年KRT风险与LN-CKD (22%) 和其他CKD相似,但低于PGD-CKD (37%).
- 多变量分析显示,与PGD-CKD相比,LN-CKD的死亡风险 (HR: 1.63) 和MACE (HR: 1.65) 较高,但与其他CKD相比,不良事件的风险相似.
结论:
- 尽管KRT风险低于PGD-CKD,但LN-CKD患者的死亡率和MACE风险增加,与高心血管负担 (其他CKD) 患者相比.
- 这些发现突显了LN-CKD中显著的心血管风险,并为预防心血管事件的策略提供了信息.
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