孕妇吸烟,怀孕期间分离蛋白尿和早产之间的关联:芬兰注册分析
Mikael O Ekblad1, Mika Gissler2,3,4,5, Päivi E Korhonen1
1Department of General Practice, Institute of Clinical Medicine, University of Turku and Turku University Hospital, Turku, Finland.
Kidney international reports
|January 15, 2025
概括
怀孕期间吸烟与分离蛋白尿症有关. 吸烟和蛋白尿都增加了早产的风险,突出了对母亲和婴儿健康结果的关键因素.
科学领域:
- 产科和妇科 产科和妇科
- 围产儿医学 围产儿医学
- 公共卫生 公共卫生
背景情况:
- 怀孕期间吸烟 (SDP) 与不良妊娠结果存在复杂的关系.
- 现有的观察结果表明,SDP具有悖论性的降低了孕前风险,这需要进一步调查具体的妊娠并发症.
- 了解吸烟,蛋白尿和早产之间的相互作用对于有针对性的干预措施至关重要.
研究的目的:
- 为了研究怀孕期间吸烟与孤立蛋白尿的发生之间的联系.
- 检查吸烟和分离蛋白尿对早产风险的独立和联合影响.
主要方法:
- 分析了芬兰791,183例单独怀孕 (2006-2018) 的大型队列研究.
- 排除标准包括先前存在的病,妊娠高血压或糖尿病.
- 逻辑和线性回归模型评估了吸烟状态,分离蛋白尿 (ICD-10代码O12) 和早产之间的关联.
主要成果:
- 14.6%的孕妇是吸烟者;其中36.9%的孕妇在第一季度戒烟.
- 继续吸烟 (OR=1.29) 和戒烟 (OR=1.31) 都与较高的单独蛋白尿的可能性有关.
- 隔离蛋白尿 (OR=1.24) 和持续吸烟 (OR=1.45) 独立地与早产风险增加有关;相互作用没有显著意义.
结论:
- 怀孕期间吸烟与隔离蛋白尿的诊断之间存在显著的关联.
- 吸烟和分离蛋白尿都独立地与早产风险增加有关.
- 这些发现强调了解决戒烟和监测怀孕期间蛋白尿的重要性.
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