代谢因素对阻塞性睡眠呼吸暂停患者左心室透静功能的影响
Yi-Fan Zhou1, Shu-Han Chen1, Wan-Da Wang1
1Department of Cardiology, The Second Affiliated Hospital of Fujian Medical University, Quanzhou, Fujian Province, People's Republic of China.
Nature and science of sleep
|January 15, 2025
概括
代谢综合征 (MS) 与更严重的阻塞性睡眠呼吸暂停 (OSA) 和心脏功能受损有关. 增加的代谢因子会增加OSA患者腹功能障碍的风险.
科学领域:
- 心脏病学 心脏病学
- 睡眠医学 睡眠医学
- 代谢障碍 代谢障碍 代谢障碍
背景情况:
- 阻塞性睡眠呼吸暂停 (OSA) 的心血管风险受到代谢因素的影响,但对心脏功能的确切影响尚不清楚.
- 代谢综合征 (MS) 是OSA患者常见的并发症,可能会加剧心血管并发症.
研究的目的:
- 为了研究代谢因素对左心室透静功能的影响,在被诊断为阻塞性睡眠呼吸暂停的患者中.
- 为了确定代谢综合征与OSA和腹功能障碍的严重程度之间的关联.
主要方法:
- 一项涉及478名OSA患者的横截面研究,对386名患者 (193名MS患者,193名无MS患者) 进行倾向性得分匹配.
- 根据呼吸暂停-呼吸暂停指数 (AHI),患者被分为轻度,中度和严重的OSA组.
- 收集的数据包括夜间多睡眠学,生物化学测试和横心脏回声学.
主要成果:
- 与没有多发性硬化症的患者相比,患有多发性硬化症的患者表现出更高的AHI和更低的夜间氧和度.
- 在MS组中,左心室尺寸 (LVEDD,LVESD,IVST,LVPWT,LAD) 和E/A比率显著增加.
- 在MS组中,E/e'比率更高,并且与MS诊断和代谢因素有正相关,这表明扩张性功能障碍. 具有五种代谢因子的患者患E/e升高的风险是4.238倍.
结论:
- 代谢综合征与增加的OSA严重程度和左心室扩张功能障碍有关.
- 越来越多的代谢因素与OSA患者患腹功能障碍的风险更高相关.
- 血压成为潜在的关键代谢因素,影响这种人群的透缩功能障碍.
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