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对常见的伤口清洁溶液的抗菌疗效和治疗指数性能进行比较,重点是含有PHMB的溶液

Fergus Watson¹, Rui Chen¹, Jeanne Saint Bezard¹

¹5D Health Protection Group Ltd, Liverpool, UK.

GMS hygiene and infection control

|January 15, 2025

概括

聚化 (PHMB) 灌溶液,特别是波洛克萨默,通过快速杀死病原体和破坏具有低细胞毒性的生物膜,有效地对抗手术部位感染. 这种组合为预防医院感染提供了一个有希望的方法.

科学领域:

微生物学微生物学
传染性疾病传染性疾病
生物医学工程生物医学工程

背景情况:

手术部位感染 (SSIs) 在全球范围内增加了患者的发病率,死亡率和医疗保健成本.
有效的伤口灌对于SSI预防至关重要,需要既具有抗菌性,又具有最小细胞毒性的解决方案.
理想的灌溶液平衡了病原体的根除与患者组织的安全性.

研究的目的:

为了比较各种伤口灌溶液的抗菌疗效和细胞毒性.
评估基于聚化物 (PHMB) 的溶液对ESKAPE病原体和生物膜的活性.
为了确定PHMB用于伤口灌的最佳度和配方.

主要方法:

测试了各种灌溶液,包括不同度的聚化物 (PHMB),和低酸.
使用杀时测试评估了对浮游生物ESKAPE病原体的抗菌疗效.
确定最小杀菌度 (MBC) 和对纤维细胞细胞毒性,以计算治疗指数 (TI).
评估了0.1%PHMB溶液中选定的生物膜破坏效果.

主要成果:

0.1%的PHMB溶液迅速使浮游生物细菌失活,在60秒内实现了>4日志减少.
0.1%的PHMB和poloxamer (PREVENTIA®手术灌) 的组合表现出最高的治疗指数,表明具有较低细胞毒性的强烈抗菌活性.
在PREVENTIA®手术灌中,显著地破坏了生物膜,在60分钟后减少了3个日志.

结论:

含有PHMB的灌溶液对医院病原体非常有效.
将0.1%的PHMB与Poloxamer结合在一起,可以提供优越的生物膜消除和有利的治疗指数.
通过向浮游生物细菌和生物膜,PREVENTIA®手术灌为预防SSI提供了一种安全有效的选择.

关键词:

逃离病原体的可能在 PHMB PHMB 中.这是SSI的SSI.抗生素的有效性抗生素的有效性细胞毒性细胞毒性波洛克萨默斯 (Poloxamer) 是一个波洛克萨默斯 (Poloxamer) 公司.聚化是一种多化.外科手术侧面感染治疗指数治疗指数伤口/手术灌

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