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结肠直肠癌和微生物群:系统审查

Nauryzbay Imanbayev¹, Yerbolat Iztleuov², Yerbol Bekmukhambetov³

¹Department of Oncology, West Kazakhstan Marat Ospanov Medical University, Aktobe, Kazakhstan.

Przeglad gastroenterologiczny

|January 15, 2025

概括

肠道微生物群调节影响结肠直肠癌 (CRC) 风险和治疗. 像短链脂肪酸 (SCFA) 这样的有益细菌和代谢产物提供保护,而益生菌可以支持CRC患者的肠道健康.

科学领域:

胃肠病学胃肠病学
在瘤学瘤学.
微生物学微生物学

背景情况:

肠道微生物组对于维持肠道屏障至关重要.
主体免疫系统显著影响肠道微生物群的组成.
失生症与各种疾病有关,包括结直肠癌 (CRC).

研究的目的:

评估微生物群调制对结直肠癌 (CRC) 的影响.
评估益生菌,益生菌,共生菌和自然变化的对CRC的影响.
审查有关肠道微生物群和CRC治疗的现有文献.

主要方法:

2010-2021年以英语出版的原始和体内研究的系统综述.
使用关键词进行PubMed搜索:CRCs,CRC治疗和微生物群调节 (益生菌,益生菌等). ) 的情况.
纳入标准侧重于分析微生物群在CRC发展和治疗中的作用的研究,最终分析了61项研究.

主要成果:

肠道微生物群的代谢物,特别是短链脂肪酸 (SCFA),如酸盐,显示出对CRC的保护作用.
脂肪酸可降低炎症,抑制结肠细胞的增殖,并促进癌细胞的亡.
降低有益细菌的水平 (例如,Bacteroides物种,Akkermansia muciniphila) 与CRC有关.

结论:

益生菌和未加工的植物食品支持健康的肠道微生物群.
精心挑选的益生菌,益生菌和共生菌可以帮助CRC患者.
微生物群调制可以成为CRC管理和治疗疗效的支持策略.

关键词:

结肠直肠癌是什么意思我们的微生物群.审查审查审查审查审查审查

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