越南儿童血囊素C和肌素的连续参考间隔
Mai Thi Chi Tran1,2, Dung Lan Dao2, Ha Thi Ngoc Bui3
1Faculty of Medical Technology, Hanoi Medical University, Vietnam.
EJIFCC
|January 15, 2025
概括
这项研究确定了越南儿童血囊C和肌素的特定年龄参考间隔,改善了早期发现功能障碍的方法. 这些发现对于在儿科护理中准确评估膜过率至关重要.
科学领域:
- 儿科脏病学 儿科脏病学
- 临床化学 临床化学
- 生物标记分析 生物标记分析
背景情况:
- 血清肌素和细胞素C是评估儿童膜过率的标准.
- 当前参考间隔的限制,特别是在广泛的年龄范围内,会影响临床敏感性.
- 这项研究解决了越南儿童年龄相关参考间隔的需求.
研究的目的:
- 在越南儿童中建立血囊C和肌素的特定年龄的参考间隔.
- 为改善儿童群体膜过率的评估提供数据.
- 为了提高诊断儿童功能障碍的临床敏感性.
主要方法:
- 招募了454名1天至18岁的健康越南儿童.
- 使用标准临床化学方法分析了血样本的囊素C和肌素.
- 通过使用Lambda-Mu-Sigma方法推导出与年龄相关的百分点图表.
主要成果:
- 血肌在出生时很高,在2-3岁之间下降,然后逐渐增加.
- 血囊C在出生时升高,在2岁时降低,直到10岁时保持稳定,然后出现轻微增加 (10-14岁),随后下降 (15-18岁).
- 两种生物标志物的动态变化被绘制在不同的年龄组.
结论:
- 可靠的实验室测试和特定年龄的参考间隔对于准确的儿科膜过评估至关重要.
- 为囊素C和肌素提供以年龄划分的参考间隔可以更好地检测功能障碍.
- 这些发现对于儿童早期脏健康监测尤为重要.
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