干细胞治疗膀再生:一个全面的系统性审查.
Ali Faegh1,2, Shima Jahani2, Fatemeh Chinisaz2
1School of Medicine, Alborz University of Medical Sciences, Karaj, Iran.
Regenerative therapy
|January 15, 2025
概括
干细胞在组织工程中显示出膀再生的希望,匹配或超过自身细胞的性能. 脂肪酸衍生和骨髓衍生中酶干细胞是再生膀组织最有效的.
科学领域:
- 再生医学是一种再生医学.
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
- 生物材料科学 生物材料科学
背景情况:
- 泌尿系统的重建带来了一些挑战.
- 组织工程为膀再生提供了一个有希望的途径.
- 为此目的,越来越多地探索基于干细胞的方法.
研究的目的:
- 对用于膀再生的组织工程中干细胞的使用进行系统审查.
- 评估各种干细胞类型的疗效和潜力.
- 为了确定膀组织工程的最佳条件和支架.
主要方法:
- 对Scopus,PubMed和Embase数据库进行系统的文献搜索 (2024年1月).
- 包括43项关于基于干细胞的膀再生的研究.
- 不包括非英语研究和评论文章.
主要成果:
- 与自身细胞相比,干细胞表现出类似或更高的再生潜力.
- 生物合成支架与干细胞具有良好的生物相容性.
- 脂肪酸衍生和骨髓衍生中酶干细胞是最常见和最有效的.
- 其他干细胞类型表现出特定的再生能力 (例如,尿膜,光滑肌肉,新血管化).
- 缺氧条件和特定的化方法可以增强组织再生.
结论:
- 干细胞具有通过组织工程进行膀再生的巨大潜力.
- 由于现有证据有限,需要进一步研究.
- 优化的脚手架材料和培养条件对于成功的结果至关重要.
相关概念视频
Stem Cell Therapy for Tissue Regeneration
4.0K
Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
Types of Stem Cells used in Stem Cell Therapy
The two main cell...
Types of Stem Cells used in Stem Cell Therapy
The two main cell...
4.0K
Adult Stem Cells
27.9K
Stem cells are undifferentiated cells that divide and produce more stem cells or progenitor cells that differentiate into mature, specialized cell types. All the cells in the body are generated from stem cells in the early embryo, but small populations of stem cells are also present in many adult tissues including the bone marrow, brain, skin, and gut. These adult stem cells typically produce the various cell types found in that tissue—to replace cells that are damaged or to continuously...
27.9K
Stem Cell Culture
5.1K
Stem cell research aims to find ways to use stem cells to regenerate and repair cellular damage. Over time, most adult cells undergo the wear and tear of aging and lose their ability to divide and repair themselves. Stem cells do not display a particular morphology or function. Adult stem cells, which exist as a small subset of cells in most tissues, keep dividing and can differentiate into a number of specialized cells generally formed by that tissue. These cells enable the body to renew and...
5.1K
Mesenchymal Stem Cells
4.6K
Mesenchymal stem cells (MSCs) are adult stem cells that can differentiate into most connective tissue cell types, except for hematopoietic cells, depending upon the source of MSCs. For example, bone-marrow-derived MSCs (BM-MSCs) can differentiate into osteocytes, hepatocytes, and pancreatic and neuronal cells. MSCs can be isolated from various sources such as bone marrow, placenta, adipose tissue, teeth, and Wharton’s jelly, a gelatinous substance in the umbilical cord. The ease of their...
4.6K


