雷达之外的高警戒药物:一个系统的审查
Michelle Santos Menezes1, Fernanda Valença-Feitosa1, Aline Santana Góes1
1Laboratory of Teaching and Research in Social Pharmacy (LEPFS), Department of Pharmacy, Federal University of Sergipe, Av. Marcelo Déda Chagas, São Cristóvão, Sergipe, Brazil.
Exploratory research in clinical and social pharmacy
|January 15, 2025
概括
某些未列入官方高警戒药物 (HAM) 清单的药物,如RISPERIDONE和PIPERACILLIN-TAZOBACTAM,由于药物错误,对重症患者构成重大风险. 这些药物值得考虑将其纳入未来的HAM清单,以提高患者安全.
科学领域:
- 药物监督 药物监督 药物监督
- 患者安全 患者安全
- 临界护理医学 临界护理医学
背景情况:
- 药物错误对患者安全构成重大威胁,特别是在重症监护机构.
- 高警戒药物 (HAM) 被认为是因为它们在错误地使用时可能造成重大伤害.
- 现有的HAM清单可能不包括所有具有造成损害高风险的药物.
研究的目的:
- 鉴定目前未被归类为高警戒药物 (HAM) 的药物,由于药物注射错误,可能增加危急病患者严重伤害的风险.
- 评估药物管理失败导致患者严重损害的可能性.
主要方法:
- 在多个数据库 (PubMed,Lilacs,Scopus,Web of Science) 和灰色文献中进行了系统的文献审查.
- 审查包括没有时间限制的研究,分析药物错误及其对重症患者的影响.
- 在对1477项研究的初步选和对50份手稿的全文评估后,包括了7篇文章.
主要成果:
- 药物错误最常发生在药物管理和处方阶段.
- 所有包括的研究都报告了药物导致患者伤害的事件.
- 里斯佩里和皮佩拉西林-塔扎巴克坦,以及传染剂类,被确定为非HAM官方清单上的药物,由于错误而增加危害风险.
结论:
- 目前未列为HAM的药物确实会在出现药物错误时对重症患者造成严重伤害的重大风险.
- 这些已识别的药物,包括Risperidone和Piperacillin-tazobactam,应该考虑将其纳入未来的高警戒药物官方清单.
- 改进HAM清单可以有助于改善药物安全协议,并减少重症监护环境中的患者伤害.
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