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在儿童急性淋巴细胞白血病的多克索鲁比基诱导疗法后,急性心室功能障碍
Rajkumar Kundavaram1, Amber Kumar1, Sushma Konnepati2
1Pediatrics, All India Institute of Medical Sciences, Bhopal, IND.
Cureus
|January 15, 2025
概括
对儿童白血病的多克索鲁比辛治疗导致心脏功能障碍. 心声谱能有效地早期检测出这些变化,使得及时的管理能够防止进展.
科学领域:
- 儿科瘤学 儿科瘤学
- 心脏病学 心脏病学
- 诊断成像 诊断成像 诊断成像
背景情况:
- 多克索鲁比对于治疗儿童急性白血病至关重要.
- 心脏毒性是多克索鲁比辛治疗的重要并发症.
- 心脏功能障碍可以在治疗期间表现为急性,早期或晚期.
研究的目的:
- 评估多克索鲁比对患有急性淋巴细胞白血病的儿童心脏功能的影响.
- 评估回声心脏学在检测多克索鲁比诱导心脏毒性的实用性.
- 为了比较 doxorubicin 诱导剂量前后的心脏参数.
主要方法:
- 招募了28名患有急性淋巴细胞白血病的儿童.
- 心声学,包括常规和组织多普勒成像,在基线和doxorubicin后72小时进行.
- 分析了两个心室的关键静缩和静缩参数.
主要成果:
- 多克索鲁比辛在两个心室中诱导了心缩和心缩功能障碍.
- 显著的下降被观察到在三 annular 平面缩,左心室分数缩短,和喷射分数.
- 发现右心室和左心室肌动脉性能指数和异体度放松时间的增加,并减少了三体和中体E速度和三体E/A比率.
结论:
- 德克索鲁比的使用会导致儿科患者的心脏功能失调,包括心脏缩和心脏缩.
- 声心图对于早期检测亚临床心脏毒性至关重要.
- 及时的心声回声评估有助于迅速管理,以减轻多克索鲁比引起的心脏损伤.
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