血清抵抗在妊娠糖尿病中增加,但在不同三季度之间没有差异
Tahmina Ferdousi1, Tania Tofail1, Sharmin Jahan1
1Department of Endocrinology, Bangabandhu Sheikh Mujib Medical University, Shahbag, Dhaka, Bangladesh.
Heliyon
|January 15, 2025
概括
与正常葡萄糖耐受性 (NGT) 相比,妊娠期糖尿病 (GDM) 的孕妇的血清抵抗水平显著更高. 抵抗素是所有三个月内GDM的可靠预测指标.
科学领域:
- 内分泌学 在内分泌学.
- 代谢障碍 代谢障碍 代谢障碍
- 怀孕并发症 怀孕并发症
背景情况:
- 阻抗素是一种炎症性脂肪基因,与胰岛素耐药性和妊娠期糖尿病 (GDM) 病原发生有关.
- 了解怀孕期间的抵抗水平对于GDM管理至关重要.
研究的目的:
- 为了比较患有GDM的孕妇和正常葡萄糖耐受 (NGT) 的孕妇之间的血清抵抗水平.
- 为了研究在怀孕的三个月内对抗素水平的潜在差异.
- 评估抵抗素作为GDM的预测剂.
主要方法:
- 一项涉及81名患有GDM和86名患有NGT的孕妇的横截面研究.
- 口服葡萄糖耐受性测试 (OGTT) 按照世卫组织2013年标准进行.
- 在禁食状态下使用三明治ELISA方法测量血清抵抗水平.
主要成果:
- 与NGT组相比,GDM组的血清抵抗水平明显较高 (p < 0.001).
- 这一差异在怀孕所有三个季度都是一致的 (p <0.001每个季度).
- 在每个组中,在三个月内都没有发现抗原水平的显著变化.
- 二元逻辑回归确定了抵抗素作为GDM的独立预测因子 (p < 0.001).
- 接收器操作特征 (ROC) 曲线分析证实了抵抗素是GDM的良好预测指标 (AUC = 0.856,p < 0.001).
结论:
- 与NGT相比,GDM的血清抵抗水平显著增加,无论妊娠年龄如何.
- 在GDM或NGT组中,抗原水平在三个月内没有显著变化.
- 抗素作为一个有价值的预测生物标志物用于妊娠糖尿病.
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