手术后的 Tongqi 配方通过 p38 MAPK 信号通路和代谢障碍改善手术后的阴茎
Mengmeng Yang1,2, Yuxuan Lu1,2, Shufan Jin2
1Affiliated Hospital of Nanjing University of Chinese Medicine & Jiangsu Province Hospital of Chinese Medicine, Nanjing, 210029, China.
Heliyon
|January 15, 2025
概括
术后通奇配方 (PTQF) 通过调节关键通路和新陈代谢,减少术后大肠 (POI) 中的炎症和肠损伤. 这项研究澄清了PTQF.
科学领域:
- 药理学和中国传统医学
- 胃肠病学 胃肠病学
- 分子生物学分子生物学
背景情况:
- 手术后阴道 (POI) 是腹部手术后的常见并发症,其特点是胃肠功能障碍.
- 目前对POI的治疗有局限性,需要探索新的治疗策略.
- 传统中医药配方,如术后通奇配方 (PTQF),在治疗POI方面表现有前途.
研究的目的:
- 阐明PTQF在治疗POI中的治疗机制.
- 研究PTQF对p38 MAPK信号通路,ZO-1蛋白表达和POI中的代谢概况的影响.
- 为了验证PTQF的抗炎和肠道保护作用.
主要方法:
- 使用UHPLC-Q-TOF-MS/MS来识别PTQF中的化合物.
- 网络药理学预测了PTQF在POI中的目标.
- 在RAW264.7细胞上进行了体外抗炎试验.
- 建立了POI的老鼠模型来评估PTQF的疗效.
- 分析了小肠病理,ZO-1表达,炎症性细胞因子,p38 MAPK通路和血清代谢.
主要成果:
- PTQF 含有 130 种已识别的化学成分.
- 在实验室中,PTQF表现出显著的抗炎作用,并减轻了大鼠的POI症状.
- PTQF调节了ZO-1蛋白表达,减少了炎症因素,并降低了p38 MAPK酸化.
- 血清代谢学确定了与肠道炎症相关的九种差异性代谢物.
结论:
- 在POI的老鼠模型中,PTQF有效地减轻了炎症和肠道损伤.
- 治疗机制包括调节炎症因素,ZO-1蛋白,p38 MAPK通路和代谢障碍.
- PTQF代表了一种有前途的治疗药物,用于治疗术后阴茎.
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