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Updated: Jun 2, 2025

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在神经病痛条件下,巨细胞通过细胞外囊泡与神经元进行神经元通信

Francesca Picco1, Lynda Zeboudj1, Silvia Oggero1

  • 1Wolfson Sensory, Pain and Regeneration Centre, King's College London, London, United Kingdom.

Heliyon
|January 15, 2025
PubMed
概括

促炎性巨细胞释放含有microRNA-155 (miR-155) 的细胞外囊泡 (EV),这些囊泡转移到神经元,增加疼痛信号. 在临床前模型中,抑制这种EV转移可以减少神经病痛.

关键词:
细胞因子 (cytokines) 是一种细胞因子.在DRG神经元中.细胞外囊泡中的细胞外囊泡.巨细胞是一个巨细胞.神经病变性疼痛 神经病变性疼痛微RNAs 是一个微型RNA.

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