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分子亚型和SWI/SNF蛋白表达在去分化/不分化子宫内膜癌中的预后值

Chae Young Shin^1,2,3, Bengul Gokbayrak^1,2, Valerie L Tao^1,3

¹Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, British Columbia, Canada.

|January 15, 2025

概括

子宫内膜癌 (EC) 的分子分类正在发展. 在罕见的无差异化/无差异化EC (DD/UDEC) 中,只有POLE突变瘤表现良好;其他亚型 (MMRd,p53abn,NSMP) 的预后不佳.

科学领域:

妇科瘤学妇科瘤学
分子病理学分子病理学
癌症基因组学癌症基因组学

背景情况:

子宫内膜癌 (EC) 的分类已经从基因病理学转向具有明显预后的分子亚型 (POLEmut,MMRd,NSMP,p53abn).
在罕见的,积极的EC基因型,如非差异化/非差异化EC (DD/UDEC) 中,分子分类的实用性仍然不清楚.

研究的目的:

在DD/UDEC.的队列中调查分子亚型 (ProMisE分类器) 的预后意义.
分析DD/UDEC中SWI/SNF染色体重塑复合体成员的表达及其潜在的预后价值.

主要方法:

一个机构对88起DD/UDEC案件进行了回顾性分析.
使用POLE测序和免疫组织化学对p53,不匹配修复蛋白和SWI/SNF蛋白进行分子亚型化 (ARID1A,ARID1B,SMARCA4,SMARCA2).

主要成果:

在80个DD/UDEC病例中分配了分子亚型:15%的POLEmut,55%的MMRd,17.5%的p53abn,12.5%的NSMP.
波莱穆特DD/UDEC表现出很好的结果,而MMRd,p53abn和NSMP亚型显示出均的不良预后.
失去了SWI/SNF蛋白 (66%的病例) 并没有显著影响预后.

结论:

在DD/UDEC中,除了POLEmut外的所有分子亚型都与攻击性行为有关.
需要进一步的研究来探索基于分子变化的DD/UDEC的向辅助疗法,以改善患者的治疗结果.

关键词:

波兰波兰波兰在 SWI/SNF 中.没有区分的子宫内膜癌.不匹配的维修维修不匹配的维修分子亚型分子亚型在 p53 里,p53 是一个 p53 号码.没有区分的子宫内膜癌.

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