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Updated: Jun 2, 2025

Combining Chemical Cross-linking and Mass Spectrometry of Intact Protein Complexes to Study the Architecture of Multi-subunit Protein Assemblies
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Combining Chemical Cross-linking and Mass Spectrometry of Intact Protein Complexes to Study the Architecture of Multi-subunit Protein Assemblies

Published on: November 28, 2017

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化学和碰撞分离的分子和PROTAC介导的蛋白质复合体的质谱分析,提供了关于分解途径的信息

Edvaldo V S Maciel1, Jonathan Eisert1, Julian Müller1

  • 1Technical University of Darmstadt, Clemens-Schöpf Institute of Organic Chemistry and Biochemistry, Department of Chemistry, Peter-Grünberg-Straße 4, 64287 Darmstadt, Germany.

Journal of the American Society for Mass Spectrometry
|January 15, 2025
PubMed
概括

分子和PROTACs诱导蛋白质调节的近距离. 原生MS揭示了这些复合物在解离时优先排出中央连接体,与自然复合物不同.

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