肺长距离:COVID-19肺炎肺组织在COVID-19肺炎后的组织病理变化
Grgur Salai1, Jasna Tekavec-Trkanjec, Ivona Kovačević
1Grgur Salai, University Hospital Dubrava, Avenija Gojka Šuška 6, 10000 Zagreb, Croatia, salai.grgur@gmail.com.
Croatian medical journal
|January 15, 2025
概括
长期COVID肺活检显示持续的扩散性气膜损伤和血管异常,表明组织恢复缓慢. 这些组织病理学变化可能解释COVID-19患者康复后症状的持续时间.
科学领域:
- 肺部病理学 肺部病理学
- 病理学 病理学 病理学
- 传染性疾病 传染性疾病
背景情况:
- 长期COVID综合征在SARS-CoV-2感染后呈现出持续的症状和放射性异常.
- 了解潜在的肺组织变化对于有效的患者管理至关重要.
研究的目的:
- 为了研究长期COVID患者肺组织的组织病理变化.
- 为了将观察到的变化与疾病持续时间和临床表现相关联.
主要方法:
- 在症状长期COVID患者中进行跨支气管肺活检的横截面研究.
- 通过使用血素-氨酸,马蒂乌斯,红和蓝,莫瓦特,TTF-1,CD34和CD68染色的组织病理学分析.
主要成果:
- 与血管异常 (VA) 相关的扩散膜损伤 (DAD) 在发病后长达9周被观察到.
- 在8-28周之间注意到炎症模式,有时与VA并发.
- 在不同的时间点确定了纤维化模式,包括后期阶段 (48-49周).
- 血管异常包括毛细血管凝血,扩张的静脉和小动脉剖析.
结论:
- 长期COVID患者的肺组织显示缓慢恢复,其特点是持续的DAD和VA.
- 这些发现表明间歇性炎症或焦点纤维化可能会随之而来的,这可能解释了长时间的症状.
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