丁,转-3'-基丁和尼古丁代谢物比率表明吸烟与牙脱落之间存在关联
Yuwei Zhang1,2, Yue Jia1,2, Changjie Sun1,2
1Key Laboratory of Shaanxi Province for Craniofacial Precision Medicine Research, College of Stomatology, Xi'an Jiaotong University, Xi'an, Shaanxi, China.
Journal of periodontology
|January 15, 2025
概括
高水平的尼古丁代谢物 (COT + HC) 会增加牙脱落的风险,而更高的尼古丁代谢物比率 (NMR) 会提供保护. 系统性炎症和胆固醇标志物部分调解了这种关系.
科学领域:
- 口腔健康 口腔健康
- 毒理学 毒理学 毒理学
- 生物标志物 生物标志物
背景情况:
- 吸烟与牙脱落有关,但特定的尼古丁代谢物,如丁 (COT) 和转-3'-基丁 (HC) 的作用尚不清楚.
- 研究COT+HC水平和尼古丁代谢物比率 (NMR) 对牙脱落的影响对于了解吸烟相关的口腔健康结果至关重要.
研究的目的:
- 为了研究血清中COT+HC水平,NMR和牙损失之间的关系.
- 确定系统性免疫炎症指数 (SII) 或单细胞与高密度脂蛋白胆固醇 (MHR) 的比率是否调解了COT + HC和牙损失之间的关联.
主要方法:
- 利用来自国家健康和营养检查调查 (NHANES) 的横截面数据.
- 使用回归模型来评估COT + HC,NMR和牙损失之间的关联.
- 应用启动链接来测试SII和MHR的调解效应.
主要成果:
- 升高的COT+HC水平与牙损失有正相关性,特别是在最高四分位数.
- 较高的NMR与牙损失负面相关.
- SII和MHR部分调解了COT + HC和牙损失之间的关系,观察到显著的间接效应.
结论:
- 血清中COT+HC水平是导致牙脱落的危险因素,而较高的NMR水平则是保护因素.
- SII和MHR在尼古丁代谢物和牙脱落之间的联系中发挥了部分调解作用,突出了炎症和脂质通路.
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