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单个和跨组织转录组推算模型在祖先群体之间的可转移性

Inti Pagnuco1, Stephen Eyre1, Magnus Rattray2

  • 1Centre for Genetics and Genomics Versus Arthritis, Centre for Musculoskeletal Research, Division of Musculoskeletal and Dermatological Sciences, The University of Manchester, Manchester, UK.

Genetic epidemiology
|January 15, 2025
PubMed
概括

全转录组关联研究 (TWAS) 依赖于准确的基因表达赋值. 这项研究发现,归算模型在同一祖先群体内表现最好,突出了需要多样化的参考面板来提高TWAS准确性.

关键词:
祖先的血统 祖先的祖先表达方式 定量特征 loci loci归算是指指责一个人.组织组织组织组织组织.转录组范围的关联研究研究.可以转让的可转让性.

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Types of Genetic Transfer Between Organisms02:18

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Genetic transfer occurs when genetic information is passed from one organism to another. It occurs via two mechanisms: vertical gene transfer and horizontal gene transfer. Vertical gene transfer occurs when genetic information is transferred from one generation to the next, which happens much more frequently than horizontal gene transfer. Both sexual and asexual reproduction are forms of vertical gene transfer, where one or more organisms pass some or all of their genome onto their progeny.